Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI
High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes h...
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| Veröffentlicht in: | Journal of magnetic resonance (1997) 2008-06, Vol.192 (2), p.258-264 |
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| container_title | Journal of magnetic resonance (1997) |
| container_volume | 192 |
| creator | Hu, Simon Lustig, Michael Chen, Albert P. Crane, Jason Kerr, Adam Kelley, Douglas A.C. Hurd, Ralph Kurhanewicz, John Nelson, Sarah J. Pauly, John M. Vigneron, Daniel B. |
| description | High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of
13C metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high-resolution
13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback
13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized
13C spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility. |
| doi_str_mv | 10.1016/j.jmr.2008.03.003 |
| format | Article |
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13C metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high-resolution
13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback
13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized
13C spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility.</description><identifier>ISSN: 1090-7807</identifier><identifier>EISSN: 1096-0856</identifier><identifier>DOI: 10.1016/j.jmr.2008.03.003</identifier><identifier>PMID: 18367420</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carbon Isotopes ; Compressed sensing ; DNP ; Hyperpolarization ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Male ; Mice ; MRSI ; Phantoms, Imaging ; Prostatic Neoplasms - metabolism ; Signal Processing, Computer-Assisted ; Sparse</subject><ispartof>Journal of magnetic resonance (1997), 2008-06, Vol.192 (2), p.258-264</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 Elsevier Inc. All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2943-ea08c653c1f82178c88a1ea93b0235e5d9db426e568ad48f6c4e8f458ba02afa3</citedby><cites>FETCH-LOGICAL-c2943-ea08c653c1f82178c88a1ea93b0235e5d9db426e568ad48f6c4e8f458ba02afa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S109078070800092X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18367420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Simon</creatorcontrib><creatorcontrib>Lustig, Michael</creatorcontrib><creatorcontrib>Chen, Albert P.</creatorcontrib><creatorcontrib>Crane, Jason</creatorcontrib><creatorcontrib>Kerr, Adam</creatorcontrib><creatorcontrib>Kelley, Douglas A.C.</creatorcontrib><creatorcontrib>Hurd, Ralph</creatorcontrib><creatorcontrib>Kurhanewicz, John</creatorcontrib><creatorcontrib>Nelson, Sarah J.</creatorcontrib><creatorcontrib>Pauly, John M.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><title>Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI</title><title>Journal of magnetic resonance (1997)</title><addtitle>J Magn Reson</addtitle><description>High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of
13C metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high-resolution
13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback
13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized
13C spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility.</description><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Compressed sensing</subject><subject>DNP</subject><subject>Hyperpolarization</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Mice</subject><subject>MRSI</subject><subject>Phantoms, Imaging</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Sparse</subject><issn>1090-7807</issn><issn>1096-0856</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtVAR_YAfwKXKqbek4zj-WCEhVQu0lYqQWDhbjjPe9TaJU3u30vLrcdkV0EtPM5p5783oPULeU6goUHG5rtZDrGoAVQGrANgrckJhJkpQXBz96aGUCuQxOU1pDUApl_CGHFPFhGxqOCGLeRimiClhVyQckx-XhQuxyKPQbzc-jAWOKzNaHHDcFMEVq92EcQq9if5XJlE2L1y_a429L9in8uv3xe1b8tqZPuG7Qz0jP798_jG_Ke--Xd_Or-5KW88aVqIBZQVnljpVU6msUoaimbEWasaRd7OubWqBXCjTNcoJ26ByDVetgdo4w87Ix73utG0H7Gx-MJpeT9EPJu50MF4_34x-pZfhUdeN5IypLHBxEIjhYYtpowefLPa9GTFsk5YgpWi4yEC6B9oYUoro_h6hoJ-i0Gudo9BPUWhgOkeROef_f_ePcfA-Az7sAZg9evQYdbIes9Odj2g3ugv-BfnfrZabDQ</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Hu, Simon</creator><creator>Lustig, Michael</creator><creator>Chen, Albert P.</creator><creator>Crane, Jason</creator><creator>Kerr, Adam</creator><creator>Kelley, Douglas A.C.</creator><creator>Hurd, Ralph</creator><creator>Kurhanewicz, John</creator><creator>Nelson, Sarah J.</creator><creator>Pauly, John M.</creator><creator>Vigneron, Daniel B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200806</creationdate><title>Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI</title><author>Hu, Simon ; Lustig, Michael ; Chen, Albert P. ; Crane, Jason ; Kerr, Adam ; Kelley, Douglas A.C. ; Hurd, Ralph ; Kurhanewicz, John ; Nelson, Sarah J. ; Pauly, John M. ; Vigneron, Daniel B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2943-ea08c653c1f82178c88a1ea93b0235e5d9db426e568ad48f6c4e8f458ba02afa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Carbon Isotopes</topic><topic>Compressed sensing</topic><topic>DNP</topic><topic>Hyperpolarization</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Mice</topic><topic>MRSI</topic><topic>Phantoms, Imaging</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Sparse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Simon</creatorcontrib><creatorcontrib>Lustig, Michael</creatorcontrib><creatorcontrib>Chen, Albert P.</creatorcontrib><creatorcontrib>Crane, Jason</creatorcontrib><creatorcontrib>Kerr, Adam</creatorcontrib><creatorcontrib>Kelley, Douglas A.C.</creatorcontrib><creatorcontrib>Hurd, Ralph</creatorcontrib><creatorcontrib>Kurhanewicz, John</creatorcontrib><creatorcontrib>Nelson, Sarah J.</creatorcontrib><creatorcontrib>Pauly, John M.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Simon</au><au>Lustig, Michael</au><au>Chen, Albert P.</au><au>Crane, Jason</au><au>Kerr, Adam</au><au>Kelley, Douglas A.C.</au><au>Hurd, Ralph</au><au>Kurhanewicz, John</au><au>Nelson, Sarah J.</au><au>Pauly, John M.</au><au>Vigneron, Daniel B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI</atitle><jtitle>Journal of magnetic resonance (1997)</jtitle><addtitle>J Magn Reson</addtitle><date>2008-06</date><risdate>2008</risdate><volume>192</volume><issue>2</issue><spage>258</spage><epage>264</epage><pages>258-264</pages><issn>1090-7807</issn><eissn>1096-0856</eissn><abstract>High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of
13C metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high-resolution
13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback
13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized
13C spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18367420</pmid><doi>10.1016/j.jmr.2008.03.003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance (1997), 2008-06, Vol.192 (2), p.258-264 |
| issn | 1090-7807 1096-0856 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carbon Isotopes Compressed sensing DNP Hyperpolarization Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Mice MRSI Phantoms, Imaging Prostatic Neoplasms - metabolism Signal Processing, Computer-Assisted Sparse |
| title | Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI |
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