Activation of the spinal sigma‐1 receptor enhances NMDA‐induced pain via PKC‐ and PKA‐dependent phosphorylation of the NR1 subunit in mice

Background and purpose: Previously we demonstrated that the spinal sigma‐1 receptor (Sig‐1 R) plays an important role in pain transmission, although the exact mechanism is still unclear. It has been suggested that Sig‐1 R agonists increase glutamate‐induced calcium influx through N‐methyl‐D‐aspartat...

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Veröffentlicht in:	British journal of pharmacology 2008-07, Vol.154 (5), p.1125-1134
Hauptverfasser:	Kim, H‐W, Roh, D‐H, Yoon, S‐Y, Seo, H‐S, Kwon, Y‐B, Han, H‐J, Kim, K‐W, Beitz, A J, Lee, J‐H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Biological and medical sciences Blotting, Western Cyclic AMP-Dependent Protein Kinases - metabolism Cyclopentanes - administration & dosage Disease Models, Animal Dose-Response Relationship, Drug Ethylenediamines - administration & dosage Immunohistochemistry Injections, Spinal Male Medical sciences Mice Mice, Inbred ICR Morpholines - administration & dosage N-Methylaspartate - administration & dosage NMDA receptor NR1 subunit pain Pain - chemically induced Pain - enzymology Pain Measurement Pharmacology. Drug treatments Phosphorylation Posterior Horn Cells - enzymology Protein Kinase C - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Receptors, sigma - drug effects Receptors, sigma - metabolism Research Papers Serine Sigma-1 Receptor Signal Processing, Computer-Assisted Signal Transduction Spinal Cord - enzymology Time Factors
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