Development of neural stem cell in the adult brain
New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progr...
Gespeichert in:
| Veröffentlicht in: | Current opinion in neurobiology 2008-02, Vol.18 (1), p.108-115 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 115 |
|---|---|
| container_issue | 1 |
| container_start_page | 108 |
| container_title | Current opinion in neurobiology |
| container_volume | 18 |
| creator | Duan, Xin Kang, Eunchai Liu, Cindy Y Ming, Guo-li Song, Hongjun |
| description | New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progress has been made in the characterization of neural stem cells and their development in the adult brain. Recent studies have also begun to reveal essential extrinsic and intrinsic molecular mechanisms that govern sequential steps of adult neurogenesis in the hippocampus and subventricular zone/olfactory bulb, from proliferation and fate specification of neural progenitors to maturation, navigation, and synaptic integration of the neuronal progeny. Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system. |
| doi_str_mv | 10.1016/j.conb.2008.04.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2464621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0959438808000251</els_id><sourcerecordid>69218746</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-81817c3499472865c20620c0adb7072c10bc2de4d28a43204c4964d3b72225bd3</originalsourceid><addsrcrecordid>eNqFkkuP1DAQhC0EYoeFP8AB5cQtod12HEdCK6HlKa3EAThbjtPDesjYg52MtP8eRzPidYCTD64qdfdXjD3l0HDg6sWucTEMDQLoBmQDwO-xDdedqJXWeJ9toG_7WgqtL9ijnHcAoIQWD9kF1y2XLcgNw9d0pCke9hTmKm6rQEuyU5Vn2leOpqnyoZpvqbLjMs3VkKwPj9mDrZ0yPTm_l-zL2zefr9_XNx_ffbh-dVO7VvRzrbnmnROy72WHWrUOQSE4sOPQQYeOw-BwJDmitlIgSCd7JUcxdIjYDqO4ZFen3MMy7Gl0ZcIymjkkv7fpzkTrzZ8_wd-ar_FoUCqpkJeA5-eAFL8vlGez93ldygaKSzaqx3Itqf4rRA5CtwhFiCehSzHnRNuf03AwKxOzMysTszIxIE1hUkzPft_jl-UMoQhengRUrnn0lEx2noKj0Sdysxmj_3f-1V92N_ngnZ2-0R3lXVxSKJwMNxkNmE9rK9ZSgC6FwJaLH52VsKA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21038520</pqid></control><display><type>article</type><title>Development of neural stem cell in the adult brain</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Duan, Xin ; Kang, Eunchai ; Liu, Cindy Y ; Ming, Guo-li ; Song, Hongjun</creator><creatorcontrib>Duan, Xin ; Kang, Eunchai ; Liu, Cindy Y ; Ming, Guo-li ; Song, Hongjun</creatorcontrib><description>New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progress has been made in the characterization of neural stem cells and their development in the adult brain. Recent studies have also begun to reveal essential extrinsic and intrinsic molecular mechanisms that govern sequential steps of adult neurogenesis in the hippocampus and subventricular zone/olfactory bulb, from proliferation and fate specification of neural progenitors to maturation, navigation, and synaptic integration of the neuronal progeny. Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system.</description><identifier>ISSN: 0959-4388</identifier><identifier>EISSN: 1873-6882</identifier><identifier>DOI: 10.1016/j.conb.2008.04.001</identifier><identifier>PMID: 18514504</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Differentiation - genetics ; Cell Lineage - genetics ; Cell Movement - genetics ; Dentate Gyrus - cytology ; Dentate Gyrus - metabolism ; Humans ; Lateral Ventricles - cytology ; Lateral Ventricles - metabolism ; Neurology ; Neurons - cytology ; Neurons - metabolism ; Olfactory Bulb - cytology ; Olfactory Bulb - metabolism ; Psychiatry ; Stem Cells - cytology ; Stem Cells - metabolism ; Telencephalon - cytology ; Telencephalon - metabolism</subject><ispartof>Current opinion in neurobiology, 2008-02, Vol.18 (1), p.108-115</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-81817c3499472865c20620c0adb7072c10bc2de4d28a43204c4964d3b72225bd3</citedby><cites>FETCH-LOGICAL-c539t-81817c3499472865c20620c0adb7072c10bc2de4d28a43204c4964d3b72225bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.conb.2008.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18514504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Xin</creatorcontrib><creatorcontrib>Kang, Eunchai</creatorcontrib><creatorcontrib>Liu, Cindy Y</creatorcontrib><creatorcontrib>Ming, Guo-li</creatorcontrib><creatorcontrib>Song, Hongjun</creatorcontrib><title>Development of neural stem cell in the adult brain</title><title>Current opinion in neurobiology</title><addtitle>Curr Opin Neurobiol</addtitle><description>New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progress has been made in the characterization of neural stem cells and their development in the adult brain. Recent studies have also begun to reveal essential extrinsic and intrinsic molecular mechanisms that govern sequential steps of adult neurogenesis in the hippocampus and subventricular zone/olfactory bulb, from proliferation and fate specification of neural progenitors to maturation, navigation, and synaptic integration of the neuronal progeny. Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system.</description><subject>Animals</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Lineage - genetics</subject><subject>Cell Movement - genetics</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - metabolism</subject><subject>Humans</subject><subject>Lateral Ventricles - cytology</subject><subject>Lateral Ventricles - metabolism</subject><subject>Neurology</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Olfactory Bulb - cytology</subject><subject>Olfactory Bulb - metabolism</subject><subject>Psychiatry</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Telencephalon - cytology</subject><subject>Telencephalon - metabolism</subject><issn>0959-4388</issn><issn>1873-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP1DAQhC0EYoeFP8AB5cQtod12HEdCK6HlKa3EAThbjtPDesjYg52MtP8eRzPidYCTD64qdfdXjD3l0HDg6sWucTEMDQLoBmQDwO-xDdedqJXWeJ9toG_7WgqtL9ijnHcAoIQWD9kF1y2XLcgNw9d0pCke9hTmKm6rQEuyU5Vn2leOpqnyoZpvqbLjMs3VkKwPj9mDrZ0yPTm_l-zL2zefr9_XNx_ffbh-dVO7VvRzrbnmnROy72WHWrUOQSE4sOPQQYeOw-BwJDmitlIgSCd7JUcxdIjYDqO4ZFen3MMy7Gl0ZcIymjkkv7fpzkTrzZ8_wd-ar_FoUCqpkJeA5-eAFL8vlGez93ldygaKSzaqx3Itqf4rRA5CtwhFiCehSzHnRNuf03AwKxOzMysTszIxIE1hUkzPft_jl-UMoQhengRUrnn0lEx2noKj0Sdysxmj_3f-1V92N_ngnZ2-0R3lXVxSKJwMNxkNmE9rK9ZSgC6FwJaLH52VsKA</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Duan, Xin</creator><creator>Kang, Eunchai</creator><creator>Liu, Cindy Y</creator><creator>Ming, Guo-li</creator><creator>Song, Hongjun</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080201</creationdate><title>Development of neural stem cell in the adult brain</title><author>Duan, Xin ; Kang, Eunchai ; Liu, Cindy Y ; Ming, Guo-li ; Song, Hongjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-81817c3499472865c20620c0adb7072c10bc2de4d28a43204c4964d3b72225bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Lineage - genetics</topic><topic>Cell Movement - genetics</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - metabolism</topic><topic>Humans</topic><topic>Lateral Ventricles - cytology</topic><topic>Lateral Ventricles - metabolism</topic><topic>Neurology</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - metabolism</topic><topic>Psychiatry</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Telencephalon - cytology</topic><topic>Telencephalon - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Xin</creatorcontrib><creatorcontrib>Kang, Eunchai</creatorcontrib><creatorcontrib>Liu, Cindy Y</creatorcontrib><creatorcontrib>Ming, Guo-li</creatorcontrib><creatorcontrib>Song, Hongjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Xin</au><au>Kang, Eunchai</au><au>Liu, Cindy Y</au><au>Ming, Guo-li</au><au>Song, Hongjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of neural stem cell in the adult brain</atitle><jtitle>Current opinion in neurobiology</jtitle><addtitle>Curr Opin Neurobiol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>18</volume><issue>1</issue><spage>108</spage><epage>115</epage><pages>108-115</pages><issn>0959-4388</issn><eissn>1873-6882</eissn><abstract>New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progress has been made in the characterization of neural stem cells and their development in the adult brain. Recent studies have also begun to reveal essential extrinsic and intrinsic molecular mechanisms that govern sequential steps of adult neurogenesis in the hippocampus and subventricular zone/olfactory bulb, from proliferation and fate specification of neural progenitors to maturation, navigation, and synaptic integration of the neuronal progeny. Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18514504</pmid><doi>10.1016/j.conb.2008.04.001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4388 |
| ispartof | Current opinion in neurobiology, 2008-02, Vol.18 (1), p.108-115 |
| issn | 0959-4388 1873-6882 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2464621 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Differentiation - genetics Cell Lineage - genetics Cell Movement - genetics Dentate Gyrus - cytology Dentate Gyrus - metabolism Humans Lateral Ventricles - cytology Lateral Ventricles - metabolism Neurology Neurons - cytology Neurons - metabolism Olfactory Bulb - cytology Olfactory Bulb - metabolism Psychiatry Stem Cells - cytology Stem Cells - metabolism Telencephalon - cytology Telencephalon - metabolism |
| title | Development of neural stem cell in the adult brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A57%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20neural%20stem%20cell%20in%20the%20adult%20brain&rft.jtitle=Current%20opinion%20in%20neurobiology&rft.au=Duan,%20Xin&rft.date=2008-02-01&rft.volume=18&rft.issue=1&rft.spage=108&rft.epage=115&rft.pages=108-115&rft.issn=0959-4388&rft.eissn=1873-6882&rft_id=info:doi/10.1016/j.conb.2008.04.001&rft_dat=%3Cproquest_pubme%3E69218746%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21038520&rft_id=info:pmid/18514504&rft_els_id=1_s2_0_S0959438808000251&rfr_iscdi=true |