Detailed comparison of expressed and native voltage-gated proton channel currents

Two years ago, genes coding for voltage-gated proton channels in humans, mice and Ciona intestinalis were discovered. Transfection of cDNA encoding the human HVCN1 (H V 1) or mouse (mVSOP) ortholog of HVCN1 into mammalian cells results in currents that are extremely similar to native proton currents...

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Veröffentlicht in:	The Journal of physiology 2008-05, Vol.586 (10), p.2477-2486
Hauptverfasser:	Musset, B., Cherny, V. V., Morgan, D., Okamura, Y., Ramsey, I. S., Clapham, D. E., DeCoursey, T. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cellular Gene Expression Regulation - physiology Humans Ion Channel Gating - physiology Ion Channels - biosynthesis Ion Channels - genetics Membrane Potentials - physiology Mice Protons
Online-Zugang:	Volltext
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