No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice
To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences be...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2008, Vol.43(1), pp.41-49 |
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| creator | Nakagawa, Shinya Kataoka, Takahiro Mizuguchi, Yuko Yoshimoto, Masaaki Sakoda, Akihiro Nomura, Takaharu Wang, Da-Hong Kawabe, Atsushi Taguchi, Takehito Yamaoka, Kiyonori |
| description | To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice. |
| doi_str_mv | 10.3164/jcbn.2008042 |
| format | Article |
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Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.2008042</identifier><identifier>PMID: 18648658</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>acatalasemic mouse ; catalase ; glutathione peroxidase ; Original ; radiosensitivity ; total glutathione</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2008, Vol.43(1), pp.41-49</ispartof><rights>2008 by The Editorial Secretariat of JCBN</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><rights>Copyright © 2008 JCBN 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-eb95ef515b9f64e5df9b85c4abe359b7c80c24fa4228ef3606cd4801474e836a3</citedby><cites>FETCH-LOGICAL-c604t-eb95ef515b9f64e5df9b85c4abe359b7c80c24fa4228ef3606cd4801474e836a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459251/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459251/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1884,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18648658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagawa, Shinya</creatorcontrib><creatorcontrib>Kataoka, Takahiro</creatorcontrib><creatorcontrib>Mizuguchi, Yuko</creatorcontrib><creatorcontrib>Yoshimoto, Masaaki</creatorcontrib><creatorcontrib>Sakoda, Akihiro</creatorcontrib><creatorcontrib>Nomura, Takaharu</creatorcontrib><creatorcontrib>Wang, Da-Hong</creatorcontrib><creatorcontrib>Kawabe, Atsushi</creatorcontrib><creatorcontrib>Taguchi, Takehito</creatorcontrib><creatorcontrib>Yamaoka, Kiyonori</creatorcontrib><title>No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.</description><subject>acatalasemic mouse</subject><subject>catalase</subject><subject>glutathione peroxidase</subject><subject>Original</subject><subject>radiosensitivity</subject><subject>total glutathione</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpdkTtvFDEURi0EIptAR40sUdAwwe_1NEhJeEUKoSCI0ng811mvZuxgexPtv2dWO1oezb3FPTr6rj6EXlByyqkSb9eui6eMEE0Ee4QWVGvSSKLVY7QgLWUNIaQ9QselrAkRSirxFB1RrYRWUi_Qz-uE3wfvIUOs-BvEEmq4D3WLQ8Q3kMeCk8c_VmmA5jz1W3yZs-2DrSFF3EF9AIj4OuXRDtjGHp85W-1gC4zB4S_BwTP0xNuhwPN5n6DvHz_cXHxurr5-urw4u2qcIqI20LUSvKSya70SIHvfdlo6YTvgsu2WThPHhLeCMQ2eK6JcLzShYilAc2X5CXq3995tuhF6N72T7WDuchht3ppkg_n3EsPK3KZ7w4RsmaST4PUsyOnXBko1YygOhsFGSJtilpwrtaSETOSr_8h12uQ4fWeoEIwupWB8ot7sKZdTKRn8IQslZtec2TVn5uYm_OXf-f_Ac1UTcL4H1qXaWzgANtfgBtjbBDd0N2br4ehWNhuI_DcWAKzL</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Nakagawa, Shinya</creator><creator>Kataoka, Takahiro</creator><creator>Mizuguchi, Yuko</creator><creator>Yoshimoto, Masaaki</creator><creator>Sakoda, Akihiro</creator><creator>Nomura, Takaharu</creator><creator>Wang, Da-Hong</creator><creator>Kawabe, Atsushi</creator><creator>Taguchi, Takehito</creator><creator>Yamaoka, Kiyonori</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080701</creationdate><title>No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice</title><author>Nakagawa, Shinya ; Kataoka, Takahiro ; Mizuguchi, Yuko ; Yoshimoto, Masaaki ; Sakoda, Akihiro ; Nomura, Takaharu ; Wang, Da-Hong ; Kawabe, Atsushi ; Taguchi, Takehito ; Yamaoka, Kiyonori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-eb95ef515b9f64e5df9b85c4abe359b7c80c24fa4228ef3606cd4801474e836a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>acatalasemic mouse</topic><topic>catalase</topic><topic>glutathione peroxidase</topic><topic>Original</topic><topic>radiosensitivity</topic><topic>total glutathione</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakagawa, Shinya</creatorcontrib><creatorcontrib>Kataoka, Takahiro</creatorcontrib><creatorcontrib>Mizuguchi, Yuko</creatorcontrib><creatorcontrib>Yoshimoto, Masaaki</creatorcontrib><creatorcontrib>Sakoda, Akihiro</creatorcontrib><creatorcontrib>Nomura, Takaharu</creatorcontrib><creatorcontrib>Wang, Da-Hong</creatorcontrib><creatorcontrib>Kawabe, Atsushi</creatorcontrib><creatorcontrib>Taguchi, Takehito</creatorcontrib><creatorcontrib>Yamaoka, Kiyonori</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagawa, Shinya</au><au>Kataoka, Takahiro</au><au>Mizuguchi, Yuko</au><au>Yoshimoto, Masaaki</au><au>Sakoda, Akihiro</au><au>Nomura, Takaharu</au><au>Wang, Da-Hong</au><au>Kawabe, Atsushi</au><au>Taguchi, Takehito</au><au>Yamaoka, Kiyonori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>43</volume><issue>1</issue><spage>41</spage><epage>49</epage><pages>41-49</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>18648658</pmid><doi>10.3164/jcbn.2008042</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acatalasemic mouse catalase glutathione peroxidase Original radiosensitivity total glutathione |
| title | No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice |
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