Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB1) and receptor 2 (CB2) and the endocannabinoids, are implicated in a wide range of physiological and pat...

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Veröffentlicht in:	Arthritis research & therapy 2008-01, Vol.10 (2), p.R43-R43, Article R43
Hauptverfasser:	Richardson, Denise, Pearson, Richard G, Kurian, Nisha, Latif, M Liaque, Garle, Michael J, Barrett, David A, Kendall, David A, Scammell, Brigitte E, Reeve, Alison J, Chapman, Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amidohydrolases - analysis Amidohydrolases - metabolism Arachidonic Acids - analysis Arachidonic Acids - metabolism Arthritis, Rheumatoid - metabolism Blotting, Western Cannabinoids Cells, Cultured Chromatography, Liquid Cytokines - analysis Cytokines - metabolism Dosage and administration Drug therapy Endocannabinoids Female Fibroblasts - metabolism Glycerides - analysis Glycerides - metabolism Health aspects Humans Knee Joint - metabolism Male Mass Spectrometry Middle Aged Mitogen-Activated Protein Kinase 1 - analysis Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - analysis Mitogen-Activated Protein Kinase 3 - metabolism Osteoarthritis Osteoarthritis - metabolism Phosphorylation - drug effects Piperidines - pharmacology Polyunsaturated Alkamides - analysis Polyunsaturated Alkamides - metabolism Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Synovial fluid Synovial Fluid - chemistry Synovial Fluid - metabolism Synovial Membrane - metabolism
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