Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice

Abstract A deficit in IL-4 production has been previously reported in both diabetic human patients and non-obese diabetic (NOD) mice. In addition, re-introducing IL-4 into NOD mice systemically, or as a transgene, led to a beneficial outcome in most studies. Here, we show that prediabetic, 12-week o...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2008-05, Vol.127 (2), p.176-187
Hauptverfasser:	Creusot, Rémi J, Yaghoubi, Shahriar S, Kodama, Keiichi, Dang, Demi N, Dang, Vu H, Breckpot, Karine, Thielemans, Kris, Gambhir, Sanjiv S, Fathman, C. Garrison
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Biological and medical sciences Bioluminescence Blood Glucose - analysis Cellular gene therapy Dendritic cell Dendritic Cells - immunology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control Diabetes Mellitus, Type 1 - therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Genetic Therapy Histocompatibility Antigens - immunology Immunotherapy, Adoptive - methods Interleukin-4 Interleukin-4 - biosynthesis Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - immunology Lymph Nodes - immunology Medical sciences Mice Mice, Inbred NOD NOD mouse Oligonucleotide Array Sequence Analysis Pancreas - immunology Pancreatic lymph node Prediabetic State - genetics Prediabetic State - immunology Prediabetic State - therapy Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics Transduction, Genetic Type 1 diabetes
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