Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

Antimicrobial levels of reactive oxygen species (ROS) are produced by the mammalian host defense to kill invading bacteria and limit bacterial colonization. One main in vivo target of ROS is the thiol group of proteins. We have developed a quantitative thiol trapping technique termed OxICAT to ident...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-06, Vol.105 (24), p.8197-8202
Hauptverfasser:	Leichert, Lars I, Gehrke, Florian, Gudiseva, Harini V, Blackwell, Tom, Ilbert, Marianne, Walker, Angela K, Strahler, John R, Andrews, Philip C, Jakob, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Biochemistry Biological Sciences Cell growth Disulfides Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Hydrogen bonds Hydrogen Peroxide - pharmacology Hypochlorite Hypochlorous Acid - pharmacology Mass Spectrometry - methods Oxidation Oxidation-Reduction Oxidative stress Oxidative Stress - genetics Oxygen Proteins Proteome Proteomes Proteomics Reactive oxygen species Reactive Oxygen Species - metabolism Reactive Oxygen Species Special Feature Reagents Regulator genes Sulfhydryl Compounds - analysis Sulfhydryl Compounds - metabolism Thiols
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