Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis

Indoleamine 2,3-dioxygenase (IDO) is a negative regulator of lymphocyte responses that is expressed predominantly in macrophages and dendritic cells. We detected it at high levels in the small intestine and mesenteric lymph node of young adult mice, suggesting a role in intestinal immunity. Consiste...

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Veröffentlicht in:	Infection and Immunity 2008-07, Vol.76 (7), p.3045-3053
Hauptverfasser:	Harrington, Lynne, Srikanth, Chittur V, Antony, Reuben, Rhee, Sue J, Mellor, Andrew L, Shi, Hai Ning, Cherayil, Bobby J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - blood Bacterial Infections Bacteriology Biological and medical sciences Citrobacter Citrobacter rodentium Citrobacter rodentium - pathogenicity Colitis - immunology Colitis - microbiology Colitis - prevention & control Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - microbiology Enterobacteriaceae Infections - prevention & control Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - immunology Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology Immunoglobulin A - analysis Immunoglobulin A - blood Immunoglobulin G - blood Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microbiology Miscellaneous
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