Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria

Saxitoxin (STX) and its analogues cause the paralytic shellfish poisoning (PSP) syndrome, which afflicts human health and impacts coastal shellfish economies worldwide. PSP toxins are unique alkaloids, being produced by both prokaryotes and eukaryotes. Here we describe a candidate PSP toxin biosynth...

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Veröffentlicht in:	Applied and Environmental Microbiology 2008-07, Vol.74 (13), p.4044-4053
Hauptverfasser:	Kellmann, Ralf, Mihali, Troco Kaan, Jeon, Young Jae, Pickford, Russell, Pomati, Francesco, Neilan, Brett A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Chemical synthesis Culture Media - chemistry Cyanobacteria Cyanobacteria - classification Cyanobacteria - enzymology Cyanobacteria - genetics Cyanobacteria - growth & development Enzymology and Protein Engineering Eukaryotes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genes Marine Toxins - biosynthesis Marine Toxins - genetics Mass Spectrometry Microbiology Molecular Sequence Data Multigene Family Phylogeny Proteins Saxitoxin - biosynthesis Saxitoxin - genetics Sequence Analysis, DNA Shellfish Toxins
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