Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcgammaRIIIb is a glycosylphosphatidylinositol-l...

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Veröffentlicht in:	The Journal of experimental medicine 2008-07, Vol.205 (7), p.1573-1582
Hauptverfasser:	Willcocks, Lisa C, Lyons, Paul A, Clatworthy, Menna R, Robinson, James I, Yang, Wanling, Newland, Stephen A, Plagnol, Vincent, McGovern, Naomi N, Condliffe, Alison M, Chilvers, Edwin R, Adu, Dwomoa, Jolly, Elaine C, Watts, Richard, Lau, Yu Lung, Morgan, Ann W, Nash, Gerard, Smith, Kenneth G C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antineutrophil Cytoplasmic - immunology Antigen-Antibody Complex - genetics Antigen-Antibody Complex - immunology Autoimmunity - genetics Brief Definitive Reports Female Gene Dosage - genetics Gene Dosage - immunology Gene Expression Regulation - genetics Gene Expression Regulation - immunology Genetic Predisposition to Disease Genetic Variation - immunology GPI-Linked Proteins Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Neutrophils - immunology Receptors, IgG - genetics Receptors, IgG - immunology Vasculitis - genetics Vasculitis - immunology White People
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