Repertoire Analysis and New Pathogenic Epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) Mice

Interphotoreceptor retinoid binding protein (IRBP) is the major uveitogenic retinal antigen eliciting experimental autoimmune uveoretinitis (EAU) in mice. The most frequently used mouse strains are B10.RIII and C57BL/6, but to date only one uveitogenic epitope for each has been identified. The purpo...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-05, Vol.49 (5), p.1946-1956
Hauptverfasser:	Cortes, Lizette M, Mattapallil, Mary J, Silver, Phyllis B, Donoso, Larry A, Liou, Gregory I, Zhu, Wei, Chan, Chi-Chao, Caspi, Rachel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology CD4-CD8 Ratio CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cytokines - metabolism Eye Proteins - immunology Female H-2 Antigens - immunology Haplotypes Immunodominant Epitopes - immunology Lymphocyte Activation - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Peptide Fragments - immunology Retinitis - immunology Retinitis - pathology Retinol-Binding Proteins - immunology Uveitis - immunology Uveitis - pathology
Online-Zugang:	Volltext
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