Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice

Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD, although the underlying pathogenic mechanisms are unkn...

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Veröffentlicht in:	Nature (London) 2007-08, Vol.448 (7156), p.894-900
Hauptverfasser:	WELCH, Jeffrey M, JING LU, DUDEK, Serena M, WEINBERG, Richard J, CALAKOS, Nicole, WETSEL, William C, GUOPING FENG, RODRIGUIZ, Ramona M, TROTTA, Nicholas C, PECA, Joao, DING, Jin-Dong, FELICIANO, Catia, MENG CHEN, PAIGE ADAMS, J, JIANHONG LUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Anxiety disorders. Neuroses Biological and medical sciences Disease Models, Animal Face - pathology Facial Injuries - genetics Facial Injuries - pathology Gene Expression Regulation Genetics Grooming Hair Lesions Medical sciences Mice Mutants Mutation Mutation - genetics Neostriatum - metabolism Neostriatum - pathology Neostriatum - physiopathology Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurosciences Neuroses Obsessive-Compulsive Disorder - genetics Obsessive-Compulsive Disorder - physiopathology Obsessive-Compulsive Disorder - therapy Obsessive-compulsive disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Rodents Self-Injurious Behavior - genetics Self-Injurious Behavior - physiopathology Synapses - metabolism Synapses - pathology Synaptic Transmission Transgenic animals
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