Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease
Background Depressive symptoms of varying severity are prevalent in up to 63% of Alzheimer disease (AD) patients and often result in greater cognitive decline and increased caregiver burden. The current study aimed to determine the neural correlates of depressive symptoms in a sample of AD patients....
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| Veröffentlicht in: | Journal of psychiatry & neuroscience 2008-05, Vol.33 (3), p.218-226 |
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| creator | Levy-Cooperman, Naama, BA Burhan, Amer M., MD Rafi-Tari, Shahryar, MSc Kusano, Maggie, BSc Ramirez, Joel, MSc Caldwell, Curtis, PhD Black, Sandra E., MD |
| description | Background Depressive symptoms of varying severity are prevalent in up to 63% of Alzheimer disease (AD) patients and often result in greater cognitive decline and increased caregiver burden. The current study aimed to determine the neural correlates of depressive symptoms in a sample of AD patients. Methods Using the Cornell Scale for Depression in Dementia, we assessed 56 patients who met criteria for probable AD. Data obtained from Technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) were analyzed with the use of a magnetic resonance imaging–derived region of interest (ROI) anatomic template before and after atrophy correction and statistical parametric mapping (SPM). The following 4 frontal ROIs were investigated bilaterally: middle frontal gyrus (Brodmann’s area [BA] 46), orbitofrontal cortex (BA 11), superior prefrontal (BA 8/9) and anterior cingulate (BA 24/25/32/33). Results Depressive symptoms were present in 27 of the AD patients (48%). Patients with depressive symptoms showed less perfusion in the right superior and bilateral middle frontal gyri ( p < 0.005), left superior frontal ( p < 0.05) and anterior cingulate gyri ( p < 0.005) before atrophy correction. SPM analyses revealed significantly lower perfusion in bilateral dorsolateral and superior prefrontal cortex of patients with depressive symptoms (right, p < 0.005; left, p < 0.05). SPECT ROI analyses with atrophy correction revealed trends similar to data without atrophy correction but did not reach statistical significance. Conclusion In this study, depressive symptoms in AD patients were associated with relative hypoperfusion in the prefrontal cortex when they were compared with AD patients without depressive symptoms. These findings are consistent with previous reports in studies of primary depression suggesting that these regions are involved in affect and emotional regulation. |
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The current study aimed to determine the neural correlates of depressive symptoms in a sample of AD patients. Methods Using the Cornell Scale for Depression in Dementia, we assessed 56 patients who met criteria for probable AD. Data obtained from Technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) were analyzed with the use of a magnetic resonance imaging–derived region of interest (ROI) anatomic template before and after atrophy correction and statistical parametric mapping (SPM). The following 4 frontal ROIs were investigated bilaterally: middle frontal gyrus (Brodmann’s area [BA] 46), orbitofrontal cortex (BA 11), superior prefrontal (BA 8/9) and anterior cingulate (BA 24/25/32/33). Results Depressive symptoms were present in 27 of the AD patients (48%). Patients with depressive symptoms showed less perfusion in the right superior and bilateral middle frontal gyri ( p < 0.005), left superior frontal ( p < 0.05) and anterior cingulate gyri ( p < 0.005) before atrophy correction. SPM analyses revealed significantly lower perfusion in bilateral dorsolateral and superior prefrontal cortex of patients with depressive symptoms (right, p < 0.005; left, p < 0.05). SPECT ROI analyses with atrophy correction revealed trends similar to data without atrophy correction but did not reach statistical significance. Conclusion In this study, depressive symptoms in AD patients were associated with relative hypoperfusion in the prefrontal cortex when they were compared with AD patients without depressive symptoms. These findings are consistent with previous reports in studies of primary depression suggesting that these regions are involved in affect and emotional regulation.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>PMID: 18592038</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Ottawa, ON: Canadian Medical Association</publisher><subject>Adult and adolescent clinical studies ; Affect ; Aged ; Alzheimer Disease - epidemiology ; Alzheimer's disease ; Atrophy - epidemiology ; Atrophy - pathology ; Biological and medical sciences ; Brain ; Cerebrovascular Circulation - physiology ; Depression ; Depression - diagnosis ; Depression - epidemiology ; Depression - psychology ; Depression, Mental ; Diagnosis ; Female ; Frontal Lobe - blood supply ; Frontal Lobe - pathology ; Functional Laterality - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical Education ; Medical sciences ; Methods ; Mood disorders ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - pathology ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Paper ; Severity of Illness Index ; Studies ; Surveys and Questionnaires ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of psychiatry & neuroscience, 2008-05, Vol.33 (3), p.218-226</ispartof><rights>Canadian Medical Association</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 CMA Impact Inc.</rights><rights>Copyright Canadian Medical Association May 2008</rights><rights>2008 Canadian Medical Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441884/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441884/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20341603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18592038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levy-Cooperman, Naama, BA</creatorcontrib><creatorcontrib>Burhan, Amer M., MD</creatorcontrib><creatorcontrib>Rafi-Tari, Shahryar, MSc</creatorcontrib><creatorcontrib>Kusano, Maggie, BSc</creatorcontrib><creatorcontrib>Ramirez, Joel, MSc</creatorcontrib><creatorcontrib>Caldwell, Curtis, PhD</creatorcontrib><creatorcontrib>Black, Sandra E., MD</creatorcontrib><title>Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Depressive symptoms of varying severity are prevalent in up to 63% of Alzheimer disease (AD) patients and often result in greater cognitive decline and increased caregiver burden. The current study aimed to determine the neural correlates of depressive symptoms in a sample of AD patients. Methods Using the Cornell Scale for Depression in Dementia, we assessed 56 patients who met criteria for probable AD. Data obtained from Technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) were analyzed with the use of a magnetic resonance imaging–derived region of interest (ROI) anatomic template before and after atrophy correction and statistical parametric mapping (SPM). The following 4 frontal ROIs were investigated bilaterally: middle frontal gyrus (Brodmann’s area [BA] 46), orbitofrontal cortex (BA 11), superior prefrontal (BA 8/9) and anterior cingulate (BA 24/25/32/33). Results Depressive symptoms were present in 27 of the AD patients (48%). Patients with depressive symptoms showed less perfusion in the right superior and bilateral middle frontal gyri ( p < 0.005), left superior frontal ( p < 0.05) and anterior cingulate gyri ( p < 0.005) before atrophy correction. SPM analyses revealed significantly lower perfusion in bilateral dorsolateral and superior prefrontal cortex of patients with depressive symptoms (right, p < 0.005; left, p < 0.05). SPECT ROI analyses with atrophy correction revealed trends similar to data without atrophy correction but did not reach statistical significance. Conclusion In this study, depressive symptoms in AD patients were associated with relative hypoperfusion in the prefrontal cortex when they were compared with AD patients without depressive symptoms. These findings are consistent with previous reports in studies of primary depression suggesting that these regions are involved in affect and emotional regulation.</description><subject>Adult and adolescent clinical studies</subject><subject>Affect</subject><subject>Aged</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer's disease</subject><subject>Atrophy - epidemiology</subject><subject>Atrophy - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Depression</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>Depression, Mental</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Frontal Lobe - blood supply</subject><subject>Frontal Lobe - pathology</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Mood disorders</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - pathology</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Research Paper</subject><subject>Severity of Illness Index</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1180-4882</issn><issn>1488-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVkl1rFDEYhQdRbF39CzIIFnoxks-ZzI2wlLYWioLV65DJvLObmkmmyczi-uub0nW7I72RhHw-OS_hnBfZMWZCFIRR9jKtsUBF2pOj7E2MtwghgjB_nR1hwWuCqDjOLi-Cd6OyufUN5Ovt4AcI3RSNd7lybd7CECBGs4E8bvth9H3MjcuX9s8aTA8hb00EFeFt9qpTNsK73bzIfl6c_zj7Ulx_u7w6W14XwKt6LBjUXOmSMF43pAJKVUOIRmWHMK2A6bKtKCkb1dSYcSoq3vKS8aasSUNa0dZ0kX1-1B2mpodWgxuDsnIIpldhK70ycn7jzFqu_EYSxrAQLAmc7ASCv5sgjrI3UYO1yoGfokylBEo9gR_-AW_9FFz6nCS4opjiNC6y4hFaKQvSuM6nonoFDlJt76Az6XiZbBAl4WX5JDrj9WDu5CH06RkotRZ6o59VPZ09SMwIv8eVmmKUVzff_4P9OmdPDtg1KDuuo7fTmNIR5-D7Q1f2dvzNWQI-7gAVtbJdUE6buOcSw3CJ6JO9kDK0MRCktsaZ9OQXbCHuHcAyEonkzUPCHwKOBEeI8oreAzuZ7Oc</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Levy-Cooperman, Naama, BA</creator><creator>Burhan, Amer M., MD</creator><creator>Rafi-Tari, Shahryar, MSc</creator><creator>Kusano, Maggie, BSc</creator><creator>Ramirez, Joel, MSc</creator><creator>Caldwell, Curtis, PhD</creator><creator>Black, Sandra E., MD</creator><general>Canadian Medical Association</general><general>CMA Impact Inc</general><general>CMA Impact, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease</title><author>Levy-Cooperman, Naama, BA ; Burhan, Amer M., MD ; Rafi-Tari, Shahryar, MSc ; Kusano, Maggie, BSc ; Ramirez, Joel, MSc ; Caldwell, Curtis, PhD ; Black, Sandra E., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e579t-4e95ac62459b27e33ab22c06f0137e4c6d7326bab91453875d5645b692b2d8d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Affect</topic><topic>Aged</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer's disease</topic><topic>Atrophy - epidemiology</topic><topic>Atrophy - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Depression</topic><topic>Depression - diagnosis</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>Depression, Mental</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Frontal Lobe - blood supply</topic><topic>Frontal Lobe - pathology</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>Mood disorders</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - pathology</topic><topic>Psychiatry</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Research Paper</topic><topic>Severity of Illness Index</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levy-Cooperman, Naama, BA</creatorcontrib><creatorcontrib>Burhan, Amer M., MD</creatorcontrib><creatorcontrib>Rafi-Tari, Shahryar, MSc</creatorcontrib><creatorcontrib>Kusano, Maggie, BSc</creatorcontrib><creatorcontrib>Ramirez, Joel, MSc</creatorcontrib><creatorcontrib>Caldwell, Curtis, PhD</creatorcontrib><creatorcontrib>Black, Sandra E., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levy-Cooperman, Naama, BA</au><au>Burhan, Amer M., MD</au><au>Rafi-Tari, Shahryar, MSc</au><au>Kusano, Maggie, BSc</au><au>Ramirez, Joel, MSc</au><au>Caldwell, Curtis, PhD</au><au>Black, Sandra E., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>33</volume><issue>3</issue><spage>218</spage><epage>226</epage><pages>218-226</pages><issn>1180-4882</issn><eissn>1488-2434</eissn><coden>JPNEEF</coden><abstract>Background Depressive symptoms of varying severity are prevalent in up to 63% of Alzheimer disease (AD) patients and often result in greater cognitive decline and increased caregiver burden. The current study aimed to determine the neural correlates of depressive symptoms in a sample of AD patients. Methods Using the Cornell Scale for Depression in Dementia, we assessed 56 patients who met criteria for probable AD. Data obtained from Technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) were analyzed with the use of a magnetic resonance imaging–derived region of interest (ROI) anatomic template before and after atrophy correction and statistical parametric mapping (SPM). The following 4 frontal ROIs were investigated bilaterally: middle frontal gyrus (Brodmann’s area [BA] 46), orbitofrontal cortex (BA 11), superior prefrontal (BA 8/9) and anterior cingulate (BA 24/25/32/33). Results Depressive symptoms were present in 27 of the AD patients (48%). Patients with depressive symptoms showed less perfusion in the right superior and bilateral middle frontal gyri ( p < 0.005), left superior frontal ( p < 0.05) and anterior cingulate gyri ( p < 0.005) before atrophy correction. SPM analyses revealed significantly lower perfusion in bilateral dorsolateral and superior prefrontal cortex of patients with depressive symptoms (right, p < 0.005; left, p < 0.05). SPECT ROI analyses with atrophy correction revealed trends similar to data without atrophy correction but did not reach statistical significance. Conclusion In this study, depressive symptoms in AD patients were associated with relative hypoperfusion in the prefrontal cortex when they were compared with AD patients without depressive symptoms. These findings are consistent with previous reports in studies of primary depression suggesting that these regions are involved in affect and emotional regulation.</abstract><cop>Ottawa, ON</cop><pub>Canadian Medical Association</pub><pmid>18592038</pmid><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult and adolescent clinical studies Affect Aged Alzheimer Disease - epidemiology Alzheimer's disease Atrophy - epidemiology Atrophy - pathology Biological and medical sciences Brain Cerebrovascular Circulation - physiology Depression Depression - diagnosis Depression - epidemiology Depression - psychology Depression, Mental Diagnosis Female Frontal Lobe - blood supply Frontal Lobe - pathology Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging Male Medical Education Medical sciences Methods Mood disorders Prefrontal Cortex - blood supply Prefrontal Cortex - pathology Psychiatry Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Research Paper Severity of Illness Index Studies Surveys and Questionnaires Tomography, Emission-Computed, Single-Photon |
| title | Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease |
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