Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite

There is increasing evidence that Trypanosoma cruzi antioxidant enzymes play a key immune evasion role by protecting the parasite against macrophage-derived reactive oxygen and nitrogen species. Using T. cruzi transformed to overexpress the peroxiredoxins TcCPX (T. cruzi cytosolic tryparedoxin perox...

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Veröffentlicht in:	Biochemical journal 2008-03, Vol.410 (2), p.359-368
Hauptverfasser:	Piacenza, Lucía, Peluffo, Gonzalo, Alvarez, María Noel, Kelly, John M, Wilkinson, Shane R, Radi, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chagas Disease - epidemiology Chagas Disease - prevention & control Humans Kinetics Latin America - epidemiology Macrophages - parasitology Macrophages - physiology Mice Mutagenesis, Site-Directed Peroxiredoxins - genetics Peroxiredoxins - metabolism Peroxynitrous Acid - pharmacology Protozoan Proteins - genetics Protozoan Proteins - metabolism Recombinant Proteins - metabolism Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Virulence
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