Fjord-region Benzo[g]chrysene-11,12-dihydrodiol and Benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for Rat Liver Dihydrodiol Dehydrogenase (AKR1C9): Structural Basis for Stereochemical Preference

This study demonstrates that benzo[g]chrysene-11,12-dihydrodiol (B[g]C-11,12-dihydrodiol) derived from the fjord-region parent hydrocarbon B[g]C is oxidized by rat AKR1C9 with a k c a t/K m 100 times greater than that observed with the commonly studied bay-region benzo[a]pyrene-7,8-dihydrodiol (B[a]...

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Veröffentlicht in:	Chemical research in toxicology 2008-03, Vol.21 (3), p.668-677
Hauptverfasser:	Shultz, Carol A, Palackal, Nisha T, Mangal, Dipti, Harvey, Ronald G, Blair, Ian A, Penning, Trevor M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Alcohol Oxidoreductases - metabolism Animals Chromatography, High Pressure Liquid Chrysenes - chemistry Chrysenes - metabolism Circular Dichroism Humans In Vitro Techniques Indicators and Reagents Kinetics Liver - enzymology Liver - metabolism Mass Spectrometry Mercaptoethanol - metabolism Models, Molecular Mutation - genetics Oxidoreductases - genetics Oxidoreductases - metabolism Phenanthrenes - chemistry Phenanthrenes - metabolism Rats Rats, Inbred F344 Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Stereoisomerism Structure-Activity Relationship Substrate Specificity
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