Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells

. Objectives: Polycystin‐1 (PC1), a signalling receptor regulating Ca2+‐permeable cation channels, is mutated in autosomal dominant polycystic kidney disease, which is typically characterized by increased cell proliferation. However, the precise mechanisms by which PC1 functions on Ca2+ homeostasis...

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Veröffentlicht in:	Cell proliferation 2008-06, Vol.41 (3), p.554-573
Hauptverfasser:	Aguiari, G., Trimi, V., Bogo, M., Mangolini, A., Szabadkai, G., Pinton, P., Witzgall, R., Harris, P. C., Borea, P. A., Rizzuto, R., Del Senno, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Signaling Cell Line Cell Line, Transformed Cell Proliferation Codon, Nonsense - genetics Cytoplasm - metabolism Enzyme Activation Humans Kidney - enzymology Kidney - pathology Models, Biological NFATC Transcription Factors - metabolism Original Polycystic Kidney, Autosomal Dominant - enzymology Polycystic Kidney, Autosomal Dominant - pathology Protein Kinase C-alpha - metabolism RNA Interference TRPP Cation Channels - metabolism
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