A potent and selective p38 inhibitor protects against bone damage in murine collagen‐induced arthritis: a comparison with neutralization of mouse TNFα

Background and purpose: The p38 kinase regulates the release of proinflammatory cytokines including tumour‐necrosis factor‐α (TNFα) and is regarded as a potential therapeutic target in rheumatoid arthritis (RA). Using the novel p38 inhibitor Org 48762‐0, we investigated the therapeutic potential of...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of pharmacology 2008-05, Vol.154 (1), p.153-164
Hauptverfasser:	Mihara, K, Almansa, C, Smeets, R L, Loomans, E E M G, Dulos, J, Vink, P M F, Rooseboom, M, Kreutzer, H, Cavalcanti, F, Boots, A M, Nelissen, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐TNFα therapy Biological and medical sciences bone damage collagen‐induced arthritis Diseases of the osteoarticular system inflammation Inflammatory joint diseases Medical sciences Org 48762‐0 p38 MAPK Pharmacology. Drug treatments proinflammatory cytokines Research Papers rheumatoid arthritis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!