MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line

Germ cell development in C. elegans requires that the X chromosomes be globally silenced during mitosis and early meiosis. We previously found that the nuclear proteins MES-2, MES-3, MES-4 and MES-6 regulate the different chromatin states of autosomes versus X chromosomes and are required for germli...

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Veröffentlicht in:	Development (Cambridge) 2006-10, Vol.133 (19), p.3907-3917
Hauptverfasser:	Bender, Laurel B, Suh, Jinkyo, Carroll, Coleen R, Fong, Youyi, Fingerman, Ian M, Briggs, Scott D, Cao, Ru, Zhang, Yi, Reinke, Valerie, Strome, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - embryology Caenorhabditis elegans - enzymology Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - analysis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Embryo, Nonmammalian - enzymology Embryonic Development - genetics Female Gene Expression Regulation, Developmental Gene Silencing Germ Cells - cytology Germ Cells - metabolism Histone-Lysine N-Methyltransferase - analysis Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Male Meiosis - genetics Methylation Mitosis - genetics Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Protein Methyltransferases Transcription, Genetic X Chromosome - genetics X Chromosome - metabolism
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