Optic nerve axon number in mouse is regulated by PAX2

Background Papillorenal syndrome is an autosomal-dominant disease caused by mutations in the PAX2 transcription factor gene. Patients often exhibit congenital excavation of the optic nerve and a spectrum of congenital kidney abnormalities. Using a novel mouse model of this syndrome (C57BL/6J PAX2A22...

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Veröffentlicht in:	Journal of AAPOS 2008-04, Vol.12 (2), p.117-121
Hauptverfasser:	Alur, Ramakrishna P., PhD, Cox, Terry A., MD, PhD, Crawford, Mary Alice, BS, Gong, Xiaohua, PhD, Brooks, Brian P., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - ultrastructure Crosses, Genetic Disease Models, Animal Humans Kidney - abnormalities Mice Mice, Inbred C57BL Monophenol Monooxygenase - genetics Mutation Ophthalmology Optic Disk - abnormalities Optic Disk - pathology Optic Nerve - abnormalities Optic Nerve - anatomy & histology Optic Nerve - pathology PAX2 Transcription Factor - genetics
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