Phosphoinositide Binding to the Substrate Regulates Susceptibility to Proteolysis by Calpain

Calpain-mediated proteolysis regulates cytoskeletal dynamics and is altered during aging and the progression of numerous diseases or pathological conditions. Although several cytoskeletal proteins have been identified as substrates, how localized calpain activity is regulated and the mechanisms cont...

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Veröffentlicht in:	The Journal of biological chemistry 2008-04, Vol.283 (14), p.9217-9223
Hauptverfasser:	Sprague, Chelsea R., Fraley, Tamara S., Jang, Hyo Sang, Lal, Sangeet, Greenwood, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - metabolism Actins - metabolism Animals Calcium - metabolism Calpain - antagonists & inhibitors Calpain - metabolism Cell Line, Tumor Cytoskeleton - pathology Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - cytology Fibroblasts - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositol Phosphates - metabolism Protein Binding - physiology Protein Structure, Tertiary - physiology Protein Synthesis, Post-Translational Modification, and Degradation Rats Substrate Specificity - physiology
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