Mitochondrial Transcription Factor B2 Is Essential for Metabolic Function in Drosophila melanogaster Development

Characterization of the basal transcription machinery of mitochondrial DNA (mtDNA) is critical to understand mitochondrial pathophysiology. In mammalian in vitro systems, mtDNA transcription requires mtRNA polymerase, transcription factor A (TFAM), and either transcription factor B1 (TFB1M) or B2 (T...

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Veröffentlicht in:	The Journal of biological chemistry 2008-05, Vol.283 (18), p.12333-12342
Hauptverfasser:	Adán, Cristina, Matsushima, Yuichi, Hernández-Sierra, Rosana, Marco-Ferreres, Raquel, Fernández-Moreno, Miguel Ángel, González-Vioque, Emiliano, Calleja, Manuel, Aragón, Juan J., Kaguni, Laurie S., Garesse, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Animals Apoptosis Body Patterning Body Weight Cell Proliferation DNA, Mitochondrial - genetics Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Energy Metabolism Gene Expression Regulation, Developmental Gene Silencing Glycolysis Larva - cytology Larva - growth & development Longevity Mitochondria - metabolism Oxidative Phosphorylation RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Chromatin, and Epigenetics Transcription, Genetic Wings, Animal - cytology
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