Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with ove...

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Veröffentlicht in:	The Journal of clinical investigation 2008-07, Vol.118 (7), p.2438-2447
Hauptverfasser:	Kessenbrock, Kai, Fröhlich, Leopold, Sixt, Michael, Lämmermann, Tim, Pfister, Heiko, Bateman, Andrew, Belaaouaj, Azzaq, Ring, Johannes, Ollert, Markus, Fässler, Reinhard, Jenne, Dieter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory drugs Antigen-Antibody Complex - pharmacology Arthus Reaction - metabolism Arthus Reaction - pathology Arthus Reaction - prevention & control Biomedical research Bone marrow Cell Movement - drug effects Chemotaxis, Leukocyte - drug effects Enzymes Granulocytes Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Leukocyte Elastase - genetics Leukocyte Elastase - metabolism Mice Mice, Inbred Strains Mice, Knockout Microorganisms Models, Biological Myeloblastin - genetics Myeloblastin - metabolism Neutrophil Activation - drug effects Neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Ovalbumin - immunology Peptides Proteases Respiratory Burst - drug effects Stem cells Tetradecanoylphorbol Acetate - pharmacology
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