Pulmonary uptake in 67-gallium citrate scintigraphy-the 'negative heart' sign
Diffuse pulmonary uptake in 67-gallium citrate (67-Ga) scintigraphy occurs in a large number of neoplastic and inflammatory conditions. Discrimination between normal and abnormal 67-Ga uptake over the chest can be difficult and a simple visual method for identifying abnormal studies is described. A...
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| Veröffentlicht in: | Postgraduate medical journal 1989-12, Vol.65 (770), p.885-891 |
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| container_title | Postgraduate medical journal |
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| creator | Cooke, S. G. Davies, E. R. Goddard, P. R. |
| description | Diffuse pulmonary uptake in 67-gallium citrate (67-Ga) scintigraphy occurs in a large number of neoplastic and inflammatory conditions. Discrimination between normal and abnormal 67-Ga uptake over the chest can be difficult and a simple visual method for identifying abnormal studies is described. A series of 39 gallium scintigrams was retrospectively reviewed by the authors and reported without knowledge of the patients' clinical condition. Subsequent clinical follow up was obtained to establish the accuracy of the scintigram interpretation. Comparison of pulmonary uptake with that over the cardiac area is recommended as a simple and reliable method of confirming that the level of pulmonary activity is abnormal. In highly abnormal cases the cardiac area is seen as a 'negative heart' image due to the considerably increased activity in the lungs. This sign is best seen with abnormal diffuse uptake but is also seen with abnormal focal uptake. Care must be taken, as the sign may be masked, if uptake over the cardiac area itself is increased. |
| doi_str_mv | 10.1136/pgmj.65.770.885 |
| format | Article |
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G. ; Davies, E. R. ; Goddard, P. R.</creator><creatorcontrib>Cooke, S. G. ; Davies, E. R. ; Goddard, P. R.</creatorcontrib><description>Diffuse pulmonary uptake in 67-gallium citrate (67-Ga) scintigraphy occurs in a large number of neoplastic and inflammatory conditions. Discrimination between normal and abnormal 67-Ga uptake over the chest can be difficult and a simple visual method for identifying abnormal studies is described. A series of 39 gallium scintigrams was retrospectively reviewed by the authors and reported without knowledge of the patients' clinical condition. Subsequent clinical follow up was obtained to establish the accuracy of the scintigram interpretation. Comparison of pulmonary uptake with that over the cardiac area is recommended as a simple and reliable method of confirming that the level of pulmonary activity is abnormal. In highly abnormal cases the cardiac area is seen as a 'negative heart' image due to the considerably increased activity in the lungs. This sign is best seen with abnormal diffuse uptake but is also seen with abnormal focal uptake. Care must be taken, as the sign may be masked, if uptake over the cardiac area itself is increased.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.65.770.885</identifier><identifier>PMID: 2616428</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Gallium Radioisotopes ; Heart - diagnostic imaging ; Humans ; Lung Diseases - diagnostic imaging ; Lung Diseases - physiopathology ; Observer Variation ; Radiography ; Radionuclide Imaging - methods ; Radionuclide Imaging - standards ; Retrospective Studies</subject><ispartof>Postgraduate medical journal, 1989-12, Vol.65 (770), p.885-891</ispartof><rights>Copyright BMJ Publishing Group LTD Dec 1989</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b555t-e95e55dcdaa05f36cf9a4854fc8a7623046367b8886065f1713e177a0767888a3</citedby><cites>FETCH-LOGICAL-b555t-e95e55dcdaa05f36cf9a4854fc8a7623046367b8886065f1713e177a0767888a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429576/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429576/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2616428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooke, S. 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Comparison of pulmonary uptake with that over the cardiac area is recommended as a simple and reliable method of confirming that the level of pulmonary activity is abnormal. In highly abnormal cases the cardiac area is seen as a 'negative heart' image due to the considerably increased activity in the lungs. This sign is best seen with abnormal diffuse uptake but is also seen with abnormal focal uptake. Care must be taken, as the sign may be masked, if uptake over the cardiac area itself is increased.</description><subject>Gallium Radioisotopes</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Lung Diseases - physiopathology</subject><subject>Observer Variation</subject><subject>Radiography</subject><subject>Radionuclide Imaging - methods</subject><subject>Radionuclide Imaging - standards</subject><subject>Retrospective Studies</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd2L1DAUxYMo67j67JNQEFwQOps0uUn6Isigq7J-wSq-XTKdtJPZNq1Jurj_vVlmGNQXnwI5v3vvORxCnjK6ZIzL86kbdksJS6XoUmu4RxZMyLqkCuR9sqCUVyUIxR-SRzHuKGVcCXZCTirJpKj0gnz8MvfD6E24LeYpmWtbOF9IVXam7908FI1LwSRbxMb55Lpgpu1tmba2OPO2M8nd2GJrTUhnRXSdf0wetKaP9snhPSXf3r65Wr0rLz9fvF-9vizXAJBKW4MF2DQbYyi0XDZtbYQG0TbaKFlxKiSXaq21llRCyxTjlillqJIqfxp-Sl7t907zerCbxvrssscpuCEnwdE4_FvxbovdeIOVqGpQMi94cVgQxp-zjQkHFxvb98bbcY6oagHZhcjg83_A3TgHn8NhdkR1lTGWqfM91YQxxmDboxVG8a4nvOsJJWCewdxTnnj2Z4Ijfygm6-VedzHZX0fZhGuUiivAT99X-OHq4usPUdfIM_9yz6_znf8d_w1usqsW</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Cooke, S. 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G.</au><au>Davies, E. R.</au><au>Goddard, P. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary uptake in 67-gallium citrate scintigraphy-the 'negative heart' sign</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>65</volume><issue>770</issue><spage>885</spage><epage>891</epage><pages>885-891</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>Diffuse pulmonary uptake in 67-gallium citrate (67-Ga) scintigraphy occurs in a large number of neoplastic and inflammatory conditions. Discrimination between normal and abnormal 67-Ga uptake over the chest can be difficult and a simple visual method for identifying abnormal studies is described. A series of 39 gallium scintigrams was retrospectively reviewed by the authors and reported without knowledge of the patients' clinical condition. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Gallium Radioisotopes Heart - diagnostic imaging Humans Lung Diseases - diagnostic imaging Lung Diseases - physiopathology Observer Variation Radiography Radionuclide Imaging - methods Radionuclide Imaging - standards Retrospective Studies |
| title | Pulmonary uptake in 67-gallium citrate scintigraphy-the 'negative heart' sign |
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