Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia
The association between hyperostosis frontalis interna (HFI), acromegaly and hyperprolactinaemia was investigated. Thirty six acromegalic patients, of whom 19 had hyperprolactinaemia, were compared with 36 randomly-selected, age-sex matched controls. There was a higher prevalence of HFI in the skull...
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| Veröffentlicht in: | Postgraduate medical journal 1990-01, Vol.66 (771), p.16-19 |
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| creator | Fulton, J. D. Shand, J. Ritchie, D. McGhee, J. |
| description | The association between hyperostosis frontalis interna (HFI), acromegaly and hyperprolactinaemia was investigated. Thirty six acromegalic patients, of whom 19 had hyperprolactinaemia, were compared with 36 randomly-selected, age-sex matched controls. There was a higher prevalence of HFI in the skull X-rays of the acromegalic cohort (P = 0.0002) when compared to the control group. This difference was apparent in both men (P = 0.01) and women (P = 0.01). Acromegalic patients with hyperprolactinaemia also expressed HFI in a higher proportion of individuals than the control group (P = 0.0001). Intra- and interobserver variability was assessed and concordance with 100% and 97% in the moderate and severe HFI sub-groups. The following sub-group analysis was undertaken: acromegalics and those acromegalics with hyperprolactinaemia were compared with the controls and a highly significant distinction was confirmed (P = 0.0007 and P = 0.00001 respectively). A relationship between HFI severity and the patient's age was noted in both male and female acromegalics. Also, the severity of HFI appeared related to disease duration in female acromegalics. The cause of HFI remains unknown but appears to be strongly associated with acromegaly, particularly in the presence of co-existent hyperprolactinaemia. The association may have symptomatic significance and the presence of HFI should be confirmed or refuted in all patients with acromegaly. |
| doi_str_mv | 10.1136/pgmj.66.771.16 |
| format | Article |
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D. ; Shand, J. ; Ritchie, D. ; McGhee, J.</creator><creatorcontrib>Fulton, J. D. ; Shand, J. ; Ritchie, D. ; McGhee, J.</creatorcontrib><description>The association between hyperostosis frontalis interna (HFI), acromegaly and hyperprolactinaemia was investigated. Thirty six acromegalic patients, of whom 19 had hyperprolactinaemia, were compared with 36 randomly-selected, age-sex matched controls. There was a higher prevalence of HFI in the skull X-rays of the acromegalic cohort (P = 0.0002) when compared to the control group. This difference was apparent in both men (P = 0.01) and women (P = 0.01). Acromegalic patients with hyperprolactinaemia also expressed HFI in a higher proportion of individuals than the control group (P = 0.0001). Intra- and interobserver variability was assessed and concordance with 100% and 97% in the moderate and severe HFI sub-groups. The following sub-group analysis was undertaken: acromegalics and those acromegalics with hyperprolactinaemia were compared with the controls and a highly significant distinction was confirmed (P = 0.0007 and P = 0.00001 respectively). A relationship between HFI severity and the patient's age was noted in both male and female acromegalics. Also, the severity of HFI appeared related to disease duration in female acromegalics. The cause of HFI remains unknown but appears to be strongly associated with acromegaly, particularly in the presence of co-existent hyperprolactinaemia. The association may have symptomatic significance and the presence of HFI should be confirmed or refuted in all patients with acromegaly.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.66.771.16</identifier><identifier>PMID: 2349162</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Acromegaly - complications ; Acromegaly - diagnostic imaging ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Humans ; Hyperostosis Frontalis Interna - diagnostic imaging ; Hyperostosis Frontalis Interna - etiology ; Hyperprolactinemia - complications ; Male ; Middle Aged ; Observer Variation ; Radiography ; Retrospective Studies ; Skull - diagnostic imaging</subject><ispartof>Postgraduate medical journal, 1990-01, Vol.66 (771), p.16-19</ispartof><rights>Copyright BMJ Publishing Group LTD Jan 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4666-825dd5304ca02c3029553d56f37769b480e6d7da4e537af469c7595366f8ab0d3</citedby><cites>FETCH-LOGICAL-b4666-825dd5304ca02c3029553d56f37769b480e6d7da4e537af469c7595366f8ab0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429375/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429375/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2349162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fulton, J. D.</creatorcontrib><creatorcontrib>Shand, J.</creatorcontrib><creatorcontrib>Ritchie, D.</creatorcontrib><creatorcontrib>McGhee, J.</creatorcontrib><title>Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>The association between hyperostosis frontalis interna (HFI), acromegaly and hyperprolactinaemia was investigated. Thirty six acromegalic patients, of whom 19 had hyperprolactinaemia, were compared with 36 randomly-selected, age-sex matched controls. There was a higher prevalence of HFI in the skull X-rays of the acromegalic cohort (P = 0.0002) when compared to the control group. This difference was apparent in both men (P = 0.01) and women (P = 0.01). Acromegalic patients with hyperprolactinaemia also expressed HFI in a higher proportion of individuals than the control group (P = 0.0001). Intra- and interobserver variability was assessed and concordance with 100% and 97% in the moderate and severe HFI sub-groups. The following sub-group analysis was undertaken: acromegalics and those acromegalics with hyperprolactinaemia were compared with the controls and a highly significant distinction was confirmed (P = 0.0007 and P = 0.00001 respectively). A relationship between HFI severity and the patient's age was noted in both male and female acromegalics. Also, the severity of HFI appeared related to disease duration in female acromegalics. The cause of HFI remains unknown but appears to be strongly associated with acromegaly, particularly in the presence of co-existent hyperprolactinaemia. The association may have symptomatic significance and the presence of HFI should be confirmed or refuted in all patients with acromegaly.</description><subject>Acromegaly - complications</subject><subject>Acromegaly - diagnostic imaging</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperostosis Frontalis Interna - diagnostic imaging</subject><subject>Hyperostosis Frontalis Interna - etiology</subject><subject>Hyperprolactinemia - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Skull - diagnostic imaging</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd1rFDEUxUOx1LXta98KC0JBcMZ83uy8CHbRVqmtiIpv4c5MZpt1ZjJNZqX735tll6X64lMC55dzc-4h5IzRnDEBb4ZFt8wBcq1ZzuCATJiEIqNawTMyoVTwTEktnpMXMS4pZUJLdkSOuJAFAz4hl9frwQYfRx9dnDbB9yO26eb60YYeX0-xCr6zC2zXU-zr6f0GH4JvsRpdj7ZzeEIOG2yjPd2dx-T7h_ff5tfZzd3Vx_m7m6yUAJDNuKprJaiskPJKUF4oJWoFjdAailLOqIVa1yitEhqblKLSqlACoJlhSWtxTN5ufYdV2dm6sv0YsDVDcB2GtfHozN9K7-7Nwv82XPJCaJUMLnYGwT-sbBxN52Jl2xZ761fR6GJGRcF5Al_-Ay79Km2jjYZpTVMSAJaofEulDcUYbLP_CqNm043ZdGMATOrGMEgPzp8G2OO7MpKebXUXR_u4lzH8MqBTAHP7Y24Ev_z85evtJ_Mz8a-2fJnG_Gf2H2tVp8k</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Fulton, J. 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D. ; Shand, J. ; Ritchie, D. ; McGhee, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4666-825dd5304ca02c3029553d56f37769b480e6d7da4e537af469c7595366f8ab0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acromegaly - complications</topic><topic>Acromegaly - diagnostic imaging</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperostosis Frontalis Interna - diagnostic imaging</topic><topic>Hyperostosis Frontalis Interna - etiology</topic><topic>Hyperprolactinemia - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>Skull - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fulton, J. D.</creatorcontrib><creatorcontrib>Shand, J.</creatorcontrib><creatorcontrib>Ritchie, D.</creatorcontrib><creatorcontrib>McGhee, J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fulton, J. D.</au><au>Shand, J.</au><au>Ritchie, D.</au><au>McGhee, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>1990-01</date><risdate>1990</risdate><volume>66</volume><issue>771</issue><spage>16</spage><epage>19</epage><pages>16-19</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>The association between hyperostosis frontalis interna (HFI), acromegaly and hyperprolactinaemia was investigated. Thirty six acromegalic patients, of whom 19 had hyperprolactinaemia, were compared with 36 randomly-selected, age-sex matched controls. There was a higher prevalence of HFI in the skull X-rays of the acromegalic cohort (P = 0.0002) when compared to the control group. This difference was apparent in both men (P = 0.01) and women (P = 0.01). Acromegalic patients with hyperprolactinaemia also expressed HFI in a higher proportion of individuals than the control group (P = 0.0001). Intra- and interobserver variability was assessed and concordance with 100% and 97% in the moderate and severe HFI sub-groups. The following sub-group analysis was undertaken: acromegalics and those acromegalics with hyperprolactinaemia were compared with the controls and a highly significant distinction was confirmed (P = 0.0007 and P = 0.00001 respectively). A relationship between HFI severity and the patient's age was noted in both male and female acromegalics. Also, the severity of HFI appeared related to disease duration in female acromegalics. The cause of HFI remains unknown but appears to be strongly associated with acromegaly, particularly in the presence of co-existent hyperprolactinaemia. The association may have symptomatic significance and the presence of HFI should be confirmed or refuted in all patients with acromegaly.</abstract><cop>England</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>2349162</pmid><doi>10.1136/pgmj.66.771.16</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Postgraduate medical journal, 1990-01, Vol.66 (771), p.16-19 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acromegaly - complications Acromegaly - diagnostic imaging Adult Age Factors Aged Aged, 80 and over Female Humans Hyperostosis Frontalis Interna - diagnostic imaging Hyperostosis Frontalis Interna - etiology Hyperprolactinemia - complications Male Middle Aged Observer Variation Radiography Retrospective Studies Skull - diagnostic imaging |
| title | Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia |
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