Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months
Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months a...
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| Veröffentlicht in: | Postgraduate medical journal 1988-06, Vol.64 (752), p.434-437 |
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| creator | Sawyer, N. Gabriel, R. |
| description | Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months and 55 had to be withdrawn from the trial. The triamterene-containing preparation was discontinued most frequently (6/44) because of hypokalaemia (plasma potassium less than 3.0 mmol/l); amiloride (5/44) and spironolactone (1/47). The median fall in plasma potassium over 3 years in those patients not withdrawn because of hypokalaemia was similar in each case (P greater than 0.05) and possibly failed to reach significance because of the withdrawal rate (9%). The trend was for a greater fall in those patients taking triamterene. The spironolactone-containing preparation may be the least unsatisfactory of the three. |
| doi_str_mv | 10.1136/pgmj.64.752.434 |
| format | Article |
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The spironolactone-containing preparation may be the least unsatisfactory of the three.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.64.752.434</identifier><identifier>PMID: 3062604</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Aged ; Aged, 80 and over ; Benzothiadiazines ; Clinical Trials as Topic ; Diuretics ; Drug Combinations ; Female ; Heart Failure - drug therapy ; Humans ; Hypokalemia - chemically induced ; Male ; Random Allocation ; Sodium Chloride Symporter Inhibitors - adverse effects ; Sodium Chloride Symporter Inhibitors - therapeutic use</subject><ispartof>Postgraduate medical journal, 1988-06, Vol.64 (752), p.434-437</ispartof><rights>Copyright BMJ Publishing Group LTD Jun 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4044-51a26e169bcf28a5a79086061851d2ec03d05760bd9e757b1c630de17884c6e83</citedby><cites>FETCH-LOGICAL-b4044-51a26e169bcf28a5a79086061851d2ec03d05760bd9e757b1c630de17884c6e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2428868/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2428868/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3062604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawyer, N.</creatorcontrib><creatorcontrib>Gabriel, R.</creatorcontrib><title>Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months and 55 had to be withdrawn from the trial. The triamterene-containing preparation was discontinued most frequently (6/44) because of hypokalaemia (plasma potassium less than 3.0 mmol/l); amiloride (5/44) and spironolactone (1/47). The median fall in plasma potassium over 3 years in those patients not withdrawn because of hypokalaemia was similar in each case (P greater than 0.05) and possibly failed to reach significance because of the withdrawal rate (9%). The trend was for a greater fall in those patients taking triamterene. The spironolactone-containing preparation may be the least unsatisfactory of the three.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Benzothiadiazines</subject><subject>Clinical Trials as Topic</subject><subject>Diuretics</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Heart Failure - drug therapy</subject><subject>Humans</subject><subject>Hypokalemia - chemically induced</subject><subject>Male</subject><subject>Random Allocation</subject><subject>Sodium Chloride Symporter Inhibitors - adverse effects</subject><subject>Sodium Chloride Symporter Inhibitors - therapeutic use</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc2P0zAQxS0EWsrCmROSJW5I6fortntBggoWpAo4QDlaTjJt3SZxsJ3Vdk_86ThqVcGJi314v_dmRg-hl5TMKeXyZth2-7kUc1WyueDiEZpRIRcFUaV8jGaEcFaUQvGn6FmMe0IoV4JeoStOJJNEzNDvb8FvA8To7gDvjoM_2NZC5yx2PYa2gdAe8WCTgz5FnOzB9VucdgEgv84-uAbw4JPNAWNXxMGGCWjcGCC5Gte-q1yf7b6PeOPDZArpWER3jzvfp118jp5sbBvhxfm_Rj8-fvi-_FSsvt5-Xr5bFZUgQhQltUwClYuq3jBtS6sWREsiqS5pw6AmvCGlkqRqFqBKVdFactIAVVqLWoLm1-jtKXcYqw6aOt8TbGuG4DobjsZbZ_5VerczW39nmGBayyng9Tkg-F8jxGT2fgx93tlQpYhmnGiSqZsTVQcfY4DNZQIlZmrMTI0ZKUxuzOTGsuPV34td-HNFWS9OuosJ7i-yDQcjFVel-bJemvf650pytTbrzL858VWe87_hfwC5zLLB</recordid><startdate>19880601</startdate><enddate>19880601</enddate><creator>Sawyer, N.</creator><creator>Gabriel, R.</creator><general>The Fellowship of Postgraduate Medicine</general><general>Oxford University Press</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19880601</creationdate><title>Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months</title><author>Sawyer, N. ; Gabriel, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4044-51a26e169bcf28a5a79086061851d2ec03d05760bd9e757b1c630de17884c6e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Benzothiadiazines</topic><topic>Clinical Trials as Topic</topic><topic>Diuretics</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Heart Failure - drug therapy</topic><topic>Humans</topic><topic>Hypokalemia - chemically induced</topic><topic>Male</topic><topic>Random Allocation</topic><topic>Sodium Chloride Symporter Inhibitors - adverse effects</topic><topic>Sodium Chloride Symporter Inhibitors - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawyer, N.</creatorcontrib><creatorcontrib>Gabriel, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawyer, N.</au><au>Gabriel, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>1988-06-01</date><risdate>1988</risdate><volume>64</volume><issue>752</issue><spage>434</spage><epage>437</epage><pages>434-437</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months and 55 had to be withdrawn from the trial. The triamterene-containing preparation was discontinued most frequently (6/44) because of hypokalaemia (plasma potassium less than 3.0 mmol/l); amiloride (5/44) and spironolactone (1/47). The median fall in plasma potassium over 3 years in those patients not withdrawn because of hypokalaemia was similar in each case (P greater than 0.05) and possibly failed to reach significance because of the withdrawal rate (9%). The trend was for a greater fall in those patients taking triamterene. The spironolactone-containing preparation may be the least unsatisfactory of the three.</abstract><cop>England</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>3062604</pmid><doi>10.1136/pgmj.64.752.434</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Postgraduate medical journal, 1988-06, Vol.64 (752), p.434-437 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Benzothiadiazines Clinical Trials as Topic Diuretics Drug Combinations Female Heart Failure - drug therapy Humans Hypokalemia - chemically induced Male Random Allocation Sodium Chloride Symporter Inhibitors - adverse effects Sodium Chloride Symporter Inhibitors - therapeutic use |
| title | Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months |
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