Chemotherapeutic studies on experimental Schistosoma mansoni infection of Mastomys natalensis

Chemotherapeutic studies on experimental Schistosoma mansoni infection of Mastomys natalensis

Comparative chemotherapeutic studies on various well known or newly developed schistosomicidal agents have been carried out in Mastomys natalensis experimentally infected with Schistosoma mansoni. Hycanthone, lucanthone, niridazole, Mirasan, the experimental compounds HOE S616, HOE S683, HOE S688, a...

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Veröffentlicht in:Bulletin of the World Health Organization 1971, Vol.44 (6), p.739-750
Hauptverfasser: Lämmler, G, Petrányi, G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Mice
Schistosoma mansoni
Schistosomiasis - drug therapy
Schistosomicides - administration & dosage
Schistosomicides - therapeutic use
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container_title Bulletin of the World Health Organization
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creator Lämmler, G
Petrányi, G
description Comparative chemotherapeutic studies on various well known or newly developed schistosomicidal agents have been carried out in Mastomys natalensis experimentally infected with Schistosoma mansoni. Hycanthone, lucanthone, niridazole, Mirasan, the experimental compounds HOE S616, HOE S683, HOE S688, and HOE S201, tartar emetic, stibophen, and stibocaptate acid have shown marked activity when administered in standard daily dosages for 5 consecutive days. Dehydroemetine and bis (p-rosaniline pamoate) proved to be ineffective. The mode of action and the dose-activity relationship of hycanthone methanesulfonate are discussed and compared with the results found for other antimonial and non-antimonial substances.
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subjects Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Mice
Schistosoma mansoni
Schistosomiasis - drug therapy
Schistosomicides - administration & dosage
Schistosomicides - therapeutic use
title Chemotherapeutic studies on experimental Schistosoma mansoni infection of Mastomys natalensis
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