Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

Hyaluronan (HA) is a major glycosaminoglycan in the extracellular matrix whose expression is tightly linked to multidrug resistance and tumor progression. In this study we investigated HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell transcription factor) in both...

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Veröffentlicht in:	The Journal of biological chemistry 2008-06, Vol.283 (25), p.17635-17651
Hauptverfasser:	Bourguignon, Lilly Y.W., Peyrollier, Karine, Xia, Weiliang, Gilad, Eli
Format:	Artikel
Sprache:	eng
Schlagworte:	Ankyrins - metabolism ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological Transport Breast Neoplasms - drug therapy Cell Line, Tumor Disease Progression Female Gene Expression Regulation, Neoplastic Homeodomain Proteins - metabolism Humans Hyaluronan Receptors - chemistry Hyaluronic Acid - chemistry Mechanisms of Signal Transduction Nanog Homeobox Protein Ovarian Neoplasms - drug therapy STAT3 Transcription Factor - metabolism Stem Cells - metabolism
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