Early Stages of Amyloid Fibril Formation Studied by Liquid-State NMR: The Peptide Hormone Glucagon

The 29-residue peptide hormone glucagon forms amyloid fibrils within a few hours at low pH. In this study, we use glucagon as a model system to investigate fibril formation by liquid-state 1H-NMR spectroscopy One-dimensional, correlation, and diffusion experiments monitoring the fibril formation pro...

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Veröffentlicht in:	Biophysical journal 2008-07, Vol.95 (1), p.366-377
Hauptverfasser:	Svane, Anna Sigrid Pii, Jahn, Kasper, Deva, Taru, Malmendal, Anders, Otzen, Daniel Erik, Dittmer, Jens, Nielsen, Niels Chr
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amyloid - chemistry Amyloid - ultrastructure Computer Simulation Crystallization - methods Decay Deuterium Glucagon - chemistry Hormones Magnetic Resonance Spectroscopy - methods Models, Chemical Models, Molecular Monitoring Monomers NMR Nuclear magnetic resonance Peptides Phase Transition Protein Conformation Proteins Solutions Spectroscopy, Imaging, Other Techniques Trimers
Online-Zugang:	Volltext
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