Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model

DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local and systemic rhIGF‐I treatment increased new bone formation. However, only systemic delivery produced measurable concentrations of rhIGF‐I in...

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Veröffentlicht in:	Journal of bone and mineral research 2006-09, Vol.21 (9), p.1359-1366
Hauptverfasser:	Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - drug effects anabolic agents Animals distraction osteogenesis Electron Probe Microanalysis Humans Injections, Intralesional - instrumentation Injections, Intralesional - methods Insulin-Like Growth Factor I - administration & dosage limb lengthening Male Mice Mice, Inbred C57BL Models, Animal Models, Biological Osteogenesis - drug effects osteoporosis Osteotomy - rehabilitation Radiography Recombinant Proteins - administration & dosage Tibia - cytology Tibia - diagnostic imaging
Online-Zugang:	Volltext
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