PATHOGENESIS OF CHOLESTEROL GALLSTONES

PATHOGENESIS OF CHOLESTEROL GALLSTONES

Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formatio...

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Veröffentlicht in:HPB Surgery 1991-02, Vol.1991 (2), p.79-102
Hauptverfasser: Strasberg, S M, Clavien, P A, Harvey, P R
Format: Artikel
Sprache:eng
Schlagworte:
Bile - chemistry
Cholelithiasis - chemistry
Cholelithiasis - etiology
Cholesterol - analysis
Crystallization
Female
Humans
Male
Phospholipids - analysis
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Zusammenfassung:Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formation. Supersaturation is common but nucleation into crystals probably requires protein nucleating factors. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation.
ISSN:0894-8569
1607-8462
DOI:10.1155/1991/61741