Relationships between radiological and biochemical evidence of rickets in Asian schoolchildren
One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided...
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| Veröffentlicht in: | Postgraduate medical journal 1985-04, Vol.61 (714), p.307-312 |
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| creator | Abdul-Motaal, A. Gettinby, G. McIntosh, W. B. Sutherland, G. R. Dunnigan, M. G. |
| description | One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population. |
| doi_str_mv | 10.1136/pgmj.61.714.307 |
| format | Article |
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B. ; Sutherland, G. R. ; Dunnigan, M. G.</creator><creatorcontrib>Abdul-Motaal, A. ; Gettinby, G. ; McIntosh, W. B. ; Sutherland, G. R. ; Dunnigan, M. G.</creatorcontrib><description>One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.61.714.307</identifier><identifier>PMID: 4022859</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Adolescent ; Alkaline Phosphatase - blood ; Calcifediol - blood ; Child ; Humans ; Knee Joint - diagnostic imaging ; Phosphorus - blood ; Prospective Studies ; Radiography ; Retrospective Studies ; Rickets - blood ; Rickets - diagnostic imaging ; Rickets - enzymology ; Serum Albumin - metabolism</subject><ispartof>Postgraduate medical journal, 1985-04, Vol.61 (714), p.307-312</ispartof><rights>Copyright BMJ Publishing Group LTD Apr 1985</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b489t-b98cb732ec35d2e9f3fd9f54113546eb30b7e43dfe0f0a596509a0533f6d136d3</citedby><cites>FETCH-LOGICAL-b489t-b98cb732ec35d2e9f3fd9f54113546eb30b7e43dfe0f0a596509a0533f6d136d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418223/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418223/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4022859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdul-Motaal, A.</creatorcontrib><creatorcontrib>Gettinby, G.</creatorcontrib><creatorcontrib>McIntosh, W. B.</creatorcontrib><creatorcontrib>Sutherland, G. R.</creatorcontrib><creatorcontrib>Dunnigan, M. G.</creatorcontrib><title>Relationships between radiological and biochemical evidence of rickets in Asian schoolchildren</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population.</description><subject>Adolescent</subject><subject>Alkaline Phosphatase - blood</subject><subject>Calcifediol - blood</subject><subject>Child</subject><subject>Humans</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Phosphorus - blood</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Rickets - blood</subject><subject>Rickets - diagnostic imaging</subject><subject>Rickets - enzymology</subject><subject>Serum Albumin - metabolism</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1DAUhS0EKkNhzQopEhILpEzt-JVskMqIQquqPAQsWGA59s3E08Qe7Eyh_74eZjQCNqws63w-9x4fhJ4SPCeEipP1clzNBZlLwuYUy3toRphoSiy5uI9mGNOq5EzSh-hRSiuMCZWMHKEjhquq5s0Mff8Eg55c8Kl361S0MP0E8EXU1oUhLJ3RQ6G9LVoXTA_j7zvcOAveQBG6IjpzDVMqnC9Ok9O-SKYPYTC9G2wE_xg96PSQ4Mn-PEZfzt58XrwrL9-_PV-cXpYtq5upbJvatJJWYCi3FTQd7WzTcZYjciagpbiVwKjtAHdY80Zw3GjMKe2Ezb9g6TF6tfNdb9oRrAE_RT2odXSjjrcqaKf-Vrzr1TLcqIqRuqpoNnixN4jhxwbSpEaXDAyD9hA2SUlRMcwFzuDzf8BV2ESfwykiJa5JXTcyUyc7ysSQUoTusArBaluc2hanBFG5OJWLyy-e_ZngwO-bynq5012a4NdB1vFaCUklV1dfF-rbxYfXZ-Tio9ryL3d8m-f8b_gdpnKzIA</recordid><startdate>19850401</startdate><enddate>19850401</enddate><creator>Abdul-Motaal, A.</creator><creator>Gettinby, G.</creator><creator>McIntosh, W. 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| ispartof | Postgraduate medical journal, 1985-04, Vol.61 (714), p.307-312 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Alkaline Phosphatase - blood Calcifediol - blood Child Humans Knee Joint - diagnostic imaging Phosphorus - blood Prospective Studies Radiography Retrospective Studies Rickets - blood Rickets - diagnostic imaging Rickets - enzymology Serum Albumin - metabolism |
| title | Relationships between radiological and biochemical evidence of rickets in Asian schoolchildren |
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