Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease
Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS. In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidit...
Gespeichert in:
| Veröffentlicht in: | Experimental neurology 2008-05, Vol.211 (1), p.234-242 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 1 |
| container_start_page | 234 |
| container_title | Experimental neurology |
| container_volume | 211 |
| creator | Tabbal, Samer D. Ushe, Mwiza Mink, Jonathan W. Revilla, Fredy J. Wernle, Angie R. Hong, Minna Karimi, Morvarid Perlmutter, Joel S. |
| description | Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS.
In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (
n
=
42), bradykinesia (
n
=
38), and gait speed (
n
=
45). Subjects were tested in four DBS conditions: both on, left on, right on and both off. A force transducer was used to measure rigidity across the elbow, and gyroscopes were used to measure angular velocity of hand rotations for bradykinesia. About half of the subjects were rated using the Unified Parkinson Disease Rating Scale (part III) motor scores for arm rigidity and repetitive hand rotation simultaneously during the kinematic measurements. Subjects were timed walking 25 feet.
All subjects had significant improvement with bilateral STN DBS. Contralateral, ipsilateral and bilateral stimulation significantly reduced rigidity and bradykinesia. Bilateral stimulation improved rigidity more than unilateral stimulation of either side, but there was no significant difference between ipsilateral and contralateral stimulation. Although bilateral stimulation also increased hand rotation velocity more than unilateral stimulation of either side, contralateral stimulation increased hand rotation significantly more than ipsilateral stimulation. All stimulation conditions improved walking time but bilateral stimulation provided the greatest improvement.
Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS. |
| doi_str_mv | 10.1016/j.expneurol.2008.01.024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2413293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014488608000575</els_id><sourcerecordid>19337287</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-4f860774489ea909cb06d05729afcf992c491ffc08584be23a8480b2e94f9c783</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhiMEokvhFcAXuCWMHW9iX5CqihakSlzo2Zo4466XxFnspOreeHS82tUCJ06W5W9-_5qvKN5xqDjw5uO2oqddoCVOQyUAVAW8AiGfFSsOGkoha3herAC4LKVSzUXxKqUtAGgp2pfFBVe10MD1qvh1H_yAM0UcWFq6eYMDjt6ysNiBlsTS7MclA34KbIOJIRsJ0xKxG4j5XToPk3NkZ5ax6B987-c9w9CzLmK__-EDJY_MB7bDmG8pY71POYleFy8cDonenM7L4v7m8_frL-Xdt9uv11d3pV3Xci6lUw20rZRKE2rQtoOmh3UrNDrrtBZWau6cBbVWsiNRo5IKOkFaOm1bVV8Wn465u6UbqbcU5lzb7KIfMe7NhN78-xL8xjxMj0ZInpdV54APp4A4_VwozWb0ydIwYKBpSYZnphWqzWB7BG2cUorkzp9wMAd7ZmvO9szBngFusr08-fbvjn_mTroy8P4EYLI4uIjB-nTmBNSNataHCldHjvJGHz1Fk6ynYKn3MVsy_eT_W-Y3eTLBtA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19337287</pqid></control><display><type>article</type><title>Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Tabbal, Samer D. ; Ushe, Mwiza ; Mink, Jonathan W. ; Revilla, Fredy J. ; Wernle, Angie R. ; Hong, Minna ; Karimi, Morvarid ; Perlmutter, Joel S.</creator><creatorcontrib>Tabbal, Samer D. ; Ushe, Mwiza ; Mink, Jonathan W. ; Revilla, Fredy J. ; Wernle, Angie R. ; Hong, Minna ; Karimi, Morvarid ; Perlmutter, Joel S.</creatorcontrib><description>Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS.
In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (
n
=
42), bradykinesia (
n
=
38), and gait speed (
n
=
45). Subjects were tested in four DBS conditions: both on, left on, right on and both off. A force transducer was used to measure rigidity across the elbow, and gyroscopes were used to measure angular velocity of hand rotations for bradykinesia. About half of the subjects were rated using the Unified Parkinson Disease Rating Scale (part III) motor scores for arm rigidity and repetitive hand rotation simultaneously during the kinematic measurements. Subjects were timed walking 25 feet.
All subjects had significant improvement with bilateral STN DBS. Contralateral, ipsilateral and bilateral stimulation significantly reduced rigidity and bradykinesia. Bilateral stimulation improved rigidity more than unilateral stimulation of either side, but there was no significant difference between ipsilateral and contralateral stimulation. Although bilateral stimulation also increased hand rotation velocity more than unilateral stimulation of either side, contralateral stimulation increased hand rotation significantly more than ipsilateral stimulation. All stimulation conditions improved walking time but bilateral stimulation provided the greatest improvement.
Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2008.01.024</identifier><identifier>PMID: 18329019</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Bradykinesia ; brain stimulation ; Deep ; Deep Brain Stimulation - methods ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; disease ; Female ; Functional Laterality - physiology ; Gait - physiology ; Gait - radiation effects ; Humans ; Hypokinesia - etiology ; Hypokinesia - therapy ; Kinematics ; Male ; Medical sciences ; Middle Aged ; Muscle Rigidity - etiology ; Muscle Rigidity - therapy ; Neurology ; nucleus ; Parkinson ; Parkinson Disease - complications ; Rigidity ; Subthalamic ; Subthalamic Nucleus - physiopathology ; Subthalamic Nucleus - radiation effects</subject><ispartof>Experimental neurology, 2008-05, Vol.211 (1), p.234-242</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-4f860774489ea909cb06d05729afcf992c491ffc08584be23a8480b2e94f9c783</citedby><cites>FETCH-LOGICAL-c534t-4f860774489ea909cb06d05729afcf992c491ffc08584be23a8480b2e94f9c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.expneurol.2008.01.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20368657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18329019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabbal, Samer D.</creatorcontrib><creatorcontrib>Ushe, Mwiza</creatorcontrib><creatorcontrib>Mink, Jonathan W.</creatorcontrib><creatorcontrib>Revilla, Fredy J.</creatorcontrib><creatorcontrib>Wernle, Angie R.</creatorcontrib><creatorcontrib>Hong, Minna</creatorcontrib><creatorcontrib>Karimi, Morvarid</creatorcontrib><creatorcontrib>Perlmutter, Joel S.</creatorcontrib><title>Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS.
In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (
n
=
42), bradykinesia (
n
=
38), and gait speed (
n
=
45). Subjects were tested in four DBS conditions: both on, left on, right on and both off. A force transducer was used to measure rigidity across the elbow, and gyroscopes were used to measure angular velocity of hand rotations for bradykinesia. About half of the subjects were rated using the Unified Parkinson Disease Rating Scale (part III) motor scores for arm rigidity and repetitive hand rotation simultaneously during the kinematic measurements. Subjects were timed walking 25 feet.
All subjects had significant improvement with bilateral STN DBS. Contralateral, ipsilateral and bilateral stimulation significantly reduced rigidity and bradykinesia. Bilateral stimulation improved rigidity more than unilateral stimulation of either side, but there was no significant difference between ipsilateral and contralateral stimulation. Although bilateral stimulation also increased hand rotation velocity more than unilateral stimulation of either side, contralateral stimulation increased hand rotation significantly more than ipsilateral stimulation. All stimulation conditions improved walking time but bilateral stimulation provided the greatest improvement.
Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Bradykinesia</subject><subject>brain stimulation</subject><subject>Deep</subject><subject>Deep Brain Stimulation - methods</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>disease</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Gait - physiology</subject><subject>Gait - radiation effects</subject><subject>Humans</subject><subject>Hypokinesia - etiology</subject><subject>Hypokinesia - therapy</subject><subject>Kinematics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle Rigidity - etiology</subject><subject>Muscle Rigidity - therapy</subject><subject>Neurology</subject><subject>nucleus</subject><subject>Parkinson</subject><subject>Parkinson Disease - complications</subject><subject>Rigidity</subject><subject>Subthalamic</subject><subject>Subthalamic Nucleus - physiopathology</subject><subject>Subthalamic Nucleus - radiation effects</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEokvhFcAXuCWMHW9iX5CqihakSlzo2Zo4466XxFnspOreeHS82tUCJ06W5W9-_5qvKN5xqDjw5uO2oqddoCVOQyUAVAW8AiGfFSsOGkoha3herAC4LKVSzUXxKqUtAGgp2pfFBVe10MD1qvh1H_yAM0UcWFq6eYMDjt6ysNiBlsTS7MclA34KbIOJIRsJ0xKxG4j5XToPk3NkZ5ax6B987-c9w9CzLmK__-EDJY_MB7bDmG8pY71POYleFy8cDonenM7L4v7m8_frL-Xdt9uv11d3pV3Xci6lUw20rZRKE2rQtoOmh3UrNDrrtBZWau6cBbVWsiNRo5IKOkFaOm1bVV8Wn465u6UbqbcU5lzb7KIfMe7NhN78-xL8xjxMj0ZInpdV54APp4A4_VwozWb0ydIwYKBpSYZnphWqzWB7BG2cUorkzp9wMAd7ZmvO9szBngFusr08-fbvjn_mTroy8P4EYLI4uIjB-nTmBNSNataHCldHjvJGHz1Fk6ynYKn3MVsy_eT_W-Y3eTLBtA</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Tabbal, Samer D.</creator><creator>Ushe, Mwiza</creator><creator>Mink, Jonathan W.</creator><creator>Revilla, Fredy J.</creator><creator>Wernle, Angie R.</creator><creator>Hong, Minna</creator><creator>Karimi, Morvarid</creator><creator>Perlmutter, Joel S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease</title><author>Tabbal, Samer D. ; Ushe, Mwiza ; Mink, Jonathan W. ; Revilla, Fredy J. ; Wernle, Angie R. ; Hong, Minna ; Karimi, Morvarid ; Perlmutter, Joel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-4f860774489ea909cb06d05729afcf992c491ffc08584be23a8480b2e94f9c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Bradykinesia</topic><topic>brain stimulation</topic><topic>Deep</topic><topic>Deep Brain Stimulation - methods</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>disease</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Gait - physiology</topic><topic>Gait - radiation effects</topic><topic>Humans</topic><topic>Hypokinesia - etiology</topic><topic>Hypokinesia - therapy</topic><topic>Kinematics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle Rigidity - etiology</topic><topic>Muscle Rigidity - therapy</topic><topic>Neurology</topic><topic>nucleus</topic><topic>Parkinson</topic><topic>Parkinson Disease - complications</topic><topic>Rigidity</topic><topic>Subthalamic</topic><topic>Subthalamic Nucleus - physiopathology</topic><topic>Subthalamic Nucleus - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabbal, Samer D.</creatorcontrib><creatorcontrib>Ushe, Mwiza</creatorcontrib><creatorcontrib>Mink, Jonathan W.</creatorcontrib><creatorcontrib>Revilla, Fredy J.</creatorcontrib><creatorcontrib>Wernle, Angie R.</creatorcontrib><creatorcontrib>Hong, Minna</creatorcontrib><creatorcontrib>Karimi, Morvarid</creatorcontrib><creatorcontrib>Perlmutter, Joel S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabbal, Samer D.</au><au>Ushe, Mwiza</au><au>Mink, Jonathan W.</au><au>Revilla, Fredy J.</au><au>Wernle, Angie R.</au><au>Hong, Minna</au><au>Karimi, Morvarid</au><au>Perlmutter, Joel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>211</volume><issue>1</issue><spage>234</spage><epage>242</epage><pages>234-242</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS.
In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (
n
=
42), bradykinesia (
n
=
38), and gait speed (
n
=
45). Subjects were tested in four DBS conditions: both on, left on, right on and both off. A force transducer was used to measure rigidity across the elbow, and gyroscopes were used to measure angular velocity of hand rotations for bradykinesia. About half of the subjects were rated using the Unified Parkinson Disease Rating Scale (part III) motor scores for arm rigidity and repetitive hand rotation simultaneously during the kinematic measurements. Subjects were timed walking 25 feet.
All subjects had significant improvement with bilateral STN DBS. Contralateral, ipsilateral and bilateral stimulation significantly reduced rigidity and bradykinesia. Bilateral stimulation improved rigidity more than unilateral stimulation of either side, but there was no significant difference between ipsilateral and contralateral stimulation. Although bilateral stimulation also increased hand rotation velocity more than unilateral stimulation of either side, contralateral stimulation increased hand rotation significantly more than ipsilateral stimulation. All stimulation conditions improved walking time but bilateral stimulation provided the greatest improvement.
Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18329019</pmid><doi>10.1016/j.expneurol.2008.01.024</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 2008-05, Vol.211 (1), p.234-242 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2413293 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Analysis of Variance Biological and medical sciences Bradykinesia brain stimulation Deep Deep Brain Stimulation - methods Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases disease Female Functional Laterality - physiology Gait - physiology Gait - radiation effects Humans Hypokinesia - etiology Hypokinesia - therapy Kinematics Male Medical sciences Middle Aged Muscle Rigidity - etiology Muscle Rigidity - therapy Neurology nucleus Parkinson Parkinson Disease - complications Rigidity Subthalamic Subthalamic Nucleus - physiopathology Subthalamic Nucleus - radiation effects |
| title | Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T17%3A18%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Unilateral%20subthalamic%20nucleus%20stimulation%20has%20a%20measurable%20ipsilateral%20effect%20on%20rigidity%20and%20bradykinesia%20in%20parkinson%20disease&rft.jtitle=Experimental%20neurology&rft.au=Tabbal,%20Samer%20D.&rft.date=2008-05-01&rft.volume=211&rft.issue=1&rft.spage=234&rft.epage=242&rft.pages=234-242&rft.issn=0014-4886&rft.eissn=1090-2430&rft.coden=EXNEAC&rft_id=info:doi/10.1016/j.expneurol.2008.01.024&rft_dat=%3Cproquest_pubme%3E19337287%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19337287&rft_id=info:pmid/18329019&rft_els_id=S0014488608000575&rfr_iscdi=true |