Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice

Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofatty residuum. Here, we have reported the isolation of multipotential stem cells from hemangioma tissue that giv...

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Veröffentlicht in:	The Journal of clinical investigation 2008-07, Vol.118 (7), p.2592-2599
Hauptverfasser:	Khan, Zia A, Boscolo, Elisa, Picard, Arnaud, Psutka, Sarah, Melero-Martin, Juan M, Bartch, Tatianna C, Mulliken, John B, Bischoff, Joyce
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - chemistry Adipocytes - pathology Animals Antigens, Nuclear - analysis Antigens, Surface - analysis Biomedical research Blood vessels Blood Vessels - chemistry Blood Vessels - pathology Carrier Proteins Cell Differentiation - drug effects Cell Separation Cell Transplantation - adverse effects Cell Transplantation - methods Disease Models, Animal Endothelial Cells - chemistry Endothelial Cells - pathology Endothelium Glucose Transporter Type 1 - analysis Green Fluorescent Proteins - analysis Green Fluorescent Proteins - genetics Hemangioma Hemangioma - etiology Hemangioma - metabolism Hemangioma - pathology Humans Infant Laminin - analysis Male Mice Mice, Nude Multipotent Stem Cells - chemistry Multipotent Stem Cells - pathology Multipotent Stem Cells - transplantation Neoplastic Stem Cells - chemistry Neoplastic Stem Cells - pathology Neoplastic Stem Cells - transplantation Neovascularization Perilipin-1 Phosphoproteins - analysis Platelet Endothelial Cell Adhesion Molecule-1 - analysis Receptors, Vascular Endothelial Growth Factor - analysis Stem cells Transcription factors Transfection
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