Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression

Perturbations of stromal–epithelial interactions in the developing tumour can contribute to cancer invasion and metastasis. The structurally related metallopeptidases endothelin-converting enzyme (ECE) and neutral endopeptidase (NEP) contribute sequentially to the synthesis and inactivation of ET-1,...

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Veröffentlicht in:	British journal of cancer 2004-04, Vol.90 (8), p.1577-1582
Hauptverfasser:	Dawson, L A, Maitland, N J, Turner, A J, Usmani, B A
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Communication Cells Drug Resistance Endothelin-Converting Enzymes Enzymes Epidemiology Epithelium - physiology Gene Expression Profiling Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical research Medical sciences Metalloendopeptidases Metastasis Molecular and Cellular Pathology Molecular Medicine Neoplasm Invasiveness - physiopathology Nephrology. Urinary tract diseases Neprilysin - genetics Neprilysin - pharmacology Oncology Peptides Prostate cancer Prostatic Neoplasms - pathology Stromal Cells - physiology Tumor Cells, Cultured Tumorigenesis Tumors Tumors of the urinary system Urinary tract. Prostate gland
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