Spindle Pole Regulation by a Discrete Eg5-Interacting Domain in TPX2

Targeting protein for Xklp2 (TPX2) activates the Ser/Thr kinase Aurora A in mitosis and targets it to the mitotic spindle [1, 2]. These effects on Aurora A are mediated by the N-terminal domain of TPX2, whereas a C-terminal fragment has been reported to affect microtubule nucleation [3]. Using the X...

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Veröffentlicht in:	Current biology 2008-04, Vol.18 (7), p.519-525
Hauptverfasser:	Eckerdt, Frank, Eyers, Patrick A., Lewellyn, Andrea L., Prigent, Claude, Maller, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins Cell Cycle Proteins - metabolism Cell Line CELLBIO CELLCYCLE Cellular Biology Embryo, Nonmammalian Embryo, Nonmammalian - metabolism Embryo, Nonmammalian - physiology Embryonic Development Embryonic Development - physiology Kinesin Kinesins - metabolism Life Sciences Microtubule-Associated Proteins Microtubule-Associated Proteins - metabolism Mitosis Mitosis - physiology Mitotic Spindle Apparatus Neoplasm Proteins Neoplasm Proteins - metabolism Nuclear Proteins Nuclear Proteins - metabolism Phosphoproteins Phosphoproteins - metabolism Protein Interaction Domains and Motifs Protein Interaction Domains and Motifs - physiology Spindle Apparatus - metabolism Spindle Apparatus - physiology Xenopus Xenopus Proteins Xenopus Proteins - metabolism
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