Numerical and structural aberrations in advanced neuroblastoma tumours by CGH analysis; survival correlates with chromosome 17 status

Rapid tumour progression in neuroblastoma is associated with MYCN amplification, deletion of the short arm of chromosome 1 and gain of 17q. However, patients with advanced disease without MYCN amplification and/or 1p deletion have a very poor outcome too, which suggests other genetic defects may pre...

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Veröffentlicht in:	British journal of cancer 2000-11, Vol.83 (10), p.1295-1300
Hauptverfasser:	Cunsolo, C Lo, Bicocchi, M P, Petti, A R, Tonini, G P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Child Child, Preschool Chromosome Aberrations Chromosomes Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 17 - genetics Disease Progression Drug Resistance Epidemiology Female Gene amplification Humans Infant Infant, Newborn Loss of Heterozygosity Male Medical prognosis Medical research Medical sciences Molecular Medicine Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Neurology Nucleic Acid Hybridization Oncology Prognosis Regular regular-article Remission (Medicine) Survival Analysis Tumors Tumors of the nervous system. Phacomatoses
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