The age of onset and sex distribution of insulin-dependent diabetes mellitus in Africans in South Africa
Type I (insulin-dependent) diabetes mellitus (IDDM) appears to be rare in indigenous African populations, but little detailed information has been published. We have therefore analysed the age of onset of diabetes in 176 African patients with IDDM (age of onset < 35 years), and in 149 consecutive...
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| Veröffentlicht in: | Postgraduate medical journal 1993-07, Vol.69 (813), p.552-556 |
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| creator | Kalk, W. J. Huddle, K. R. Raal, F. J. |
| description | Type I (insulin-dependent) diabetes mellitus (IDDM) appears to be rare in indigenous African populations, but little detailed information has been published. We have therefore analysed the age of onset of diabetes in 176 African patients with IDDM (age of onset < 35 years), and in 149 consecutive white patients of European extraction for comparison. In the Africans the peak age of onset occurred at 22-23 years (median 22 years) with an earlier peak from 14 to 17 years. In the Whites, the peak was found at 12-13 years (median 12 years). In only 7% of Africans did diabetes start under the age of 12 years. There was a slight female preponderance in the Africans, especially at the ages of greatest incident (20-25 years)-F:M 1.55:1. When patients with duration of diabetes less than 5 years only were analysed (the period during which early mortality among African patients was greatly reduced) the patterns of age distribution were similar to the total respective groups. A peak incidence in the winter months was noted. |
| doi_str_mv | 10.1136/pgmj.69.813.552 |
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When patients with duration of diabetes less than 5 years only were analysed (the period during which early mortality among African patients was greatly reduced) the patterns of age distribution were similar to the total respective groups. A peak incidence in the winter months was noted.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.69.813.552</identifier><identifier>PMID: 8415343</identifier><language>eng</language><publisher>London: The Fellowship of Postgraduate Medicine</publisher><subject>Adolescent ; Adult ; African Continental Ancestry Group ; Age of Onset ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - ethnology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; European Continental Ancestry Group ; Female ; Humans ; Male ; Medical sciences ; Sex Distribution ; South Africa - epidemiology ; South Africa - ethnology</subject><ispartof>Postgraduate medical journal, 1993-07, Vol.69 (813), p.552-556</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jul 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b518t-e284f2d3229f1e502bee24ebf6860944162e23f0b648130e32c70ece28bc05123</citedby><cites>FETCH-LOGICAL-b518t-e284f2d3229f1e502bee24ebf6860944162e23f0b648130e32c70ece28bc05123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2399890/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2399890/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4885336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8415343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalk, W. J.</creatorcontrib><creatorcontrib>Huddle, K. R.</creatorcontrib><creatorcontrib>Raal, F. J.</creatorcontrib><title>The age of onset and sex distribution of insulin-dependent diabetes mellitus in Africans in South Africa</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>Type I (insulin-dependent) diabetes mellitus (IDDM) appears to be rare in indigenous African populations, but little detailed information has been published. We have therefore analysed the age of onset of diabetes in 176 African patients with IDDM (age of onset < 35 years), and in 149 consecutive white patients of European extraction for comparison. In the Africans the peak age of onset occurred at 22-23 years (median 22 years) with an earlier peak from 14 to 17 years. In the Whites, the peak was found at 12-13 years (median 12 years). In only 7% of Africans did diabetes start under the age of 12 years. There was a slight female preponderance in the Africans, especially at the ages of greatest incident (20-25 years)-F:M 1.55:1. When patients with duration of diabetes less than 5 years only were analysed (the period during which early mortality among African patients was greatly reduced) the patterns of age distribution were similar to the total respective groups. A peak incidence in the winter months was noted.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - ethnology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Sex Distribution</subject><subject>South Africa - epidemiology</subject><subject>South Africa - ethnology</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUuP0zAUhS0EGsrAmhVSJBALpHT8trNBGnV4ScNDUGZrOclN65LYxU7Q8O9xaFUBG1a2fD7fe44OQo8JXhLC5MV-M-yWslpqwpZC0DtoQbisSqyEvIsWGDNaCq7YffQgpR3GhClOztCZ5kQwzhZou95CYTdQhK4IPsFYWN8WCW6L1qUxunoaXfCz6nyaeufLFvbgW_BjJmwNI6RigL5345QyU1x20TXW_75_CdO4Pb48RPc62yd4dDzP0dfXr9art-X1xzfvVpfXZS2IHkugmne0ZZRWHQGBaQ1AOdSd1BJXnBNJgbIO15LnyBgYbRSGJn-rGywIZefo5WHufqoHaJtsNNre7KMbbPxpgnXmb8W7rdmEH4ayqtIVzgOeHwfE8H2CNJrBpSYntB7ClIySmFSazpue_gPuwhR9DmeIUlgzLvVMXRyoJoaUInQnKwSbuUIzV2hkZXIekyvMP578meDEHzvL-rOjblNj-y5a37h0wrjWgjGZsfKA5R7h9iTb-M1IxZQwH25W5urT5_c3V2pt5rUvDnyd7fzP4y_Ve8Hf</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Kalk, W. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult African Continental Ancestry Group Age of Onset Biological and medical sciences Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - ethnology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group Female Humans Male Medical sciences Sex Distribution South Africa - epidemiology South Africa - ethnology |
| title | The age of onset and sex distribution of insulin-dependent diabetes mellitus in Africans in South Africa |
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