A Demographic Analysis of the Fitness Cost of Extended Longevity in Caenorhabditis elegans
We monitored survival and reproduction of 1000 individuals of Caenorhabditis elegans wild type (N2) and 800 individuals of clk-1 and daf-2, and used biodemographic analysis to address fitness as the integrative consequence of the entire age-specific schedules of survival and reproduction. Relative t...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-02, Vol.62 (2), p.126-135 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Chen, Jianjun Senturk, Damla Wang, Jane-Ling Müller, Hans-Georg Carey, James R. Caswell, Hal Caswell-Chen, Edward P. |
| description | We monitored survival and reproduction of 1000 individuals of Caenorhabditis elegans wild type (N2) and 800 individuals of clk-1 and daf-2, and used biodemographic analysis to address fitness as the integrative consequence of the entire age-specific schedules of survival and reproduction. Relative to N2, the mutants clk-1 and daf-2 extended average life span by 27% and 111%, respectively, but reduced net reproductive rate by 44% and 18%. The net result of differences in survival and fertility was a significant differential in fitness, with both clk-1 (λ = 2.74) and daf-2 (λ = 3.78) at a disadvantage relative to N2 (λ = 3.85). Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6–7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence. |
| doi_str_mv | 10.1093/gerona/62.2.126 |
| format | Article |
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Relative to N2, the mutants clk-1 and daf-2 extended average life span by 27% and 111%, respectively, but reduced net reproductive rate by 44% and 18%. The net result of differences in survival and fertility was a significant differential in fitness, with both clk-1 (λ = 2.74) and daf-2 (λ = 3.78) at a disadvantage relative to N2 (λ = 3.85). Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6–7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/62.2.126</identifier><identifier>PMID: 17339638</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aging ; Animals ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth & development ; Caenorhabditis elegans - physiology ; Caenorhabditis elegans Proteins ; Longevity ; Mathematical Computing ; Models, Animal ; Mutation ; Receptor, Insulin ; Reproduction ; Survival Analysis</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-02, Vol.62 (2), p.126-135</ispartof><rights>Copyright Gerontological Society of America, Incorporated Feb 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-bc01cfd0b301ffd4574156c4b35e7024f8e99a8b0e6876198f972e5e0c08163e3</citedby><cites>FETCH-LOGICAL-c522t-bc01cfd0b301ffd4574156c4b35e7024f8e99a8b0e6876198f972e5e0c08163e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17339638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jianjun</creatorcontrib><creatorcontrib>Senturk, Damla</creatorcontrib><creatorcontrib>Wang, Jane-Ling</creatorcontrib><creatorcontrib>Müller, Hans-Georg</creatorcontrib><creatorcontrib>Carey, James R.</creatorcontrib><creatorcontrib>Caswell, Hal</creatorcontrib><creatorcontrib>Caswell-Chen, Edward P.</creatorcontrib><title>A Demographic Analysis of the Fitness Cost of Extended Longevity in Caenorhabditis elegans</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>We monitored survival and reproduction of 1000 individuals of Caenorhabditis elegans wild type (N2) and 800 individuals of clk-1 and daf-2, and used biodemographic analysis to address fitness as the integrative consequence of the entire age-specific schedules of survival and reproduction. Relative to N2, the mutants clk-1 and daf-2 extended average life span by 27% and 111%, respectively, but reduced net reproductive rate by 44% and 18%. The net result of differences in survival and fertility was a significant differential in fitness, with both clk-1 (λ = 2.74) and daf-2 (λ = 3.78) at a disadvantage relative to N2 (λ = 3.85). Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6–7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence.</description><subject>Aging</subject><subject>Animals</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Caenorhabditis elegans Proteins</subject><subject>Longevity</subject><subject>Mathematical Computing</subject><subject>Models, Animal</subject><subject>Mutation</subject><subject>Receptor, Insulin</subject><subject>Reproduction</subject><subject>Survival Analysis</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhk1padK0596K6aE3744k68OXwuImTWGhhbYQchGyPfYq9UobSRuy_742u6Qfc9Ew88zLaN4se0tgQaBiywGDd2Yp6IIuCBXPsnMiuSo44zfPpxxkVXAAcZa9ivEO5uD0ZXZGJGOVYOo8u13ln3Drh2B2G9vmK2fGQ7Qx932eNphf2eQwxrz2Mc21y8eErsMuX3s34INNh9y6vDbofNiYprNpmsURB-Pi6-xFb8aIb07vRfbz6vJHfV2sv37-Uq_WRcspTUXTAmn7DhoGpO-7ksuScNGWDeMogZa9wqoyqgEUSgpSqb6SFDlCC4oIhuwi-3jU3e2bLXYtuhTMqHfBbk04aG-s_rfj7EYP_kFTVikJchL4cBII_n6PMemtjS2Oo3Ho91HPW0xnncH3_4F3fh-mk0VNQQkqQKoJWh6hNvgYA_ZPmxDQs2n6aJoWVFM9mTZNvPv7A3_4k0sTUBwBGxM-PvVN-KWFZJLr65tbXX-rKXyHSpfsN3n2o6o</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Chen, Jianjun</creator><creator>Senturk, Damla</creator><creator>Wang, Jane-Ling</creator><creator>Müller, Hans-Georg</creator><creator>Carey, James R.</creator><creator>Caswell, Hal</creator><creator>Caswell-Chen, Edward P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070201</creationdate><title>A Demographic Analysis of the Fitness Cost of Extended Longevity in Caenorhabditis elegans</title><author>Chen, Jianjun ; Senturk, Damla ; Wang, Jane-Ling ; Müller, Hans-Georg ; Carey, James R. ; Caswell, Hal ; Caswell-Chen, Edward P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-bc01cfd0b301ffd4574156c4b35e7024f8e99a8b0e6876198f972e5e0c08163e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth & development</topic><topic>Caenorhabditis elegans - physiology</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Longevity</topic><topic>Mathematical Computing</topic><topic>Models, Animal</topic><topic>Mutation</topic><topic>Receptor, Insulin</topic><topic>Reproduction</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jianjun</creatorcontrib><creatorcontrib>Senturk, Damla</creatorcontrib><creatorcontrib>Wang, Jane-Ling</creatorcontrib><creatorcontrib>Müller, Hans-Georg</creatorcontrib><creatorcontrib>Carey, James R.</creatorcontrib><creatorcontrib>Caswell, Hal</creatorcontrib><creatorcontrib>Caswell-Chen, Edward P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. 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Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6–7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>17339638</pmid><doi>10.1093/gerona/62.2.126</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-02, Vol.62 (2), p.126-135 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aging Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins Longevity Mathematical Computing Models, Animal Mutation Receptor, Insulin Reproduction Survival Analysis |
| title | A Demographic Analysis of the Fitness Cost of Extended Longevity in Caenorhabditis elegans |
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