Osteoporosis and genetic influence: a three-generation study
We have studied 27 triads of mother, daughter and grandmother for possible genetic influence on distal and proximal forearm bone density, measured by single photon absorptiometry. We found a significant correlation of bone density at the proximal forearm between the mothers and grandmothers (r = 0.4...
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| Veröffentlicht in: | Postgraduate medical journal 1994-11, Vol.70 (829), p.798-800 |
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| creator | Kahn, S. A. Pace, J. E. Cox, M. L. Gau, D. W. Cox, S. A. Hodkinson, H. M. |
| description | We have studied 27 triads of mother, daughter and grandmother for possible genetic influence on distal and proximal forearm bone density, measured by single photon absorptiometry. We found a significant correlation of bone density at the proximal forearm between the mothers and grandmothers (r = 0.499, P < 0.01). There was also a weak correlation between proximal forearm bone densities of mothers and daughters (r = 0.327, P < 0.1). Significant correlations were found between the three generations for grip strength, pedometry, height and triceps skinfold thickness. There was also significant correlation between mother and grandmother for alcohol intake. There was no correlation for contraceptive pill use, smoking, dietary calcium intake, body weight or body mass index. The study concludes that, although there are similarities in bone mineral content between the three generations, genetic factors cannot be conclusively proven to be the major determinant of bone density. Lifestyle and environmental factors may have a bearing on achieving the peak bone mass and subsequent development of osteoporosis. |
| doi_str_mv | 10.1136/pgmj.70.829.798 |
| format | Article |
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A. ; Pace, J. E. ; Cox, M. L. ; Gau, D. W. ; Cox, S. A. ; Hodkinson, H. M.</creator><creatorcontrib>Kahn, S. A. ; Pace, J. E. ; Cox, M. L. ; Gau, D. W. ; Cox, S. A. ; Hodkinson, H. M.</creatorcontrib><description>We have studied 27 triads of mother, daughter and grandmother for possible genetic influence on distal and proximal forearm bone density, measured by single photon absorptiometry. We found a significant correlation of bone density at the proximal forearm between the mothers and grandmothers (r = 0.499, P < 0.01). There was also a weak correlation between proximal forearm bone densities of mothers and daughters (r = 0.327, P < 0.1). Significant correlations were found between the three generations for grip strength, pedometry, height and triceps skinfold thickness. There was also significant correlation between mother and grandmother for alcohol intake. There was no correlation for contraceptive pill use, smoking, dietary calcium intake, body weight or body mass index. The study concludes that, although there are similarities in bone mineral content between the three generations, genetic factors cannot be conclusively proven to be the major determinant of bone density. Lifestyle and environmental factors may have a bearing on achieving the peak bone mass and subsequent development of osteoporosis.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.70.829.798</identifier><identifier>PMID: 7824412</identifier><language>eng</language><publisher>London: The Fellowship of Postgraduate Medicine</publisher><subject>Absorptiometry, Photon ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Height ; Bone Density ; Cross-Sectional Studies ; Diseases of the osteoarticular system ; Family Health ; Female ; Hand Strength ; Humans ; Medical sciences ; Middle Aged ; Osteoporosis - genetics ; Osteoporosis - pathology ; Osteoporosis. Osteomalacia. Paget disease ; Skinfold Thickness</subject><ispartof>Postgraduate medical journal, 1994-11, Vol.70 (829), p.798-800</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Nov 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4338-225cc3e948ebd1e48480501471e9742ec934856d16e3d3c25bf28df6612259e73</citedby><cites>FETCH-LOGICAL-b4338-225cc3e948ebd1e48480501471e9742ec934856d16e3d3c25bf28df6612259e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397815/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397815/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3419734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7824412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahn, S. A.</creatorcontrib><creatorcontrib>Pace, J. E.</creatorcontrib><creatorcontrib>Cox, M. L.</creatorcontrib><creatorcontrib>Gau, D. W.</creatorcontrib><creatorcontrib>Cox, S. A.</creatorcontrib><creatorcontrib>Hodkinson, H. M.</creatorcontrib><title>Osteoporosis and genetic influence: a three-generation study</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>We have studied 27 triads of mother, daughter and grandmother for possible genetic influence on distal and proximal forearm bone density, measured by single photon absorptiometry. We found a significant correlation of bone density at the proximal forearm between the mothers and grandmothers (r = 0.499, P < 0.01). There was also a weak correlation between proximal forearm bone densities of mothers and daughters (r = 0.327, P < 0.1). Significant correlations were found between the three generations for grip strength, pedometry, height and triceps skinfold thickness. There was also significant correlation between mother and grandmother for alcohol intake. There was no correlation for contraceptive pill use, smoking, dietary calcium intake, body weight or body mass index. The study concludes that, although there are similarities in bone mineral content between the three generations, genetic factors cannot be conclusively proven to be the major determinant of bone density. Lifestyle and environmental factors may have a bearing on achieving the peak bone mass and subsequent development of osteoporosis.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Bone Density</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Family Health</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoporosis - genetics</subject><subject>Osteoporosis - pathology</subject><subject>Osteoporosis. Osteomalacia. 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A. ; Pace, J. E. ; Cox, M. L. ; Gau, D. W. ; Cox, S. A. ; Hodkinson, H. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4338-225cc3e948ebd1e48480501471e9742ec934856d16e3d3c25bf28df6612259e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Bone Density</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Family Health</topic><topic>Female</topic><topic>Hand Strength</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoporosis - genetics</topic><topic>Osteoporosis - pathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Skinfold Thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahn, S. A.</creatorcontrib><creatorcontrib>Pace, J. E.</creatorcontrib><creatorcontrib>Cox, M. L.</creatorcontrib><creatorcontrib>Gau, D. W.</creatorcontrib><creatorcontrib>Cox, S. A.</creatorcontrib><creatorcontrib>Hodkinson, H. 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A.</au><au>Pace, J. E.</au><au>Cox, M. L.</au><au>Gau, D. W.</au><au>Cox, S. A.</au><au>Hodkinson, H. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoporosis and genetic influence: a three-generation study</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>70</volume><issue>829</issue><spage>798</spage><epage>800</epage><pages>798-800</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>We have studied 27 triads of mother, daughter and grandmother for possible genetic influence on distal and proximal forearm bone density, measured by single photon absorptiometry. We found a significant correlation of bone density at the proximal forearm between the mothers and grandmothers (r = 0.499, P < 0.01). There was also a weak correlation between proximal forearm bone densities of mothers and daughters (r = 0.327, P < 0.1). Significant correlations were found between the three generations for grip strength, pedometry, height and triceps skinfold thickness. There was also significant correlation between mother and grandmother for alcohol intake. There was no correlation for contraceptive pill use, smoking, dietary calcium intake, body weight or body mass index. The study concludes that, although there are similarities in bone mineral content between the three generations, genetic factors cannot be conclusively proven to be the major determinant of bone density. Lifestyle and environmental factors may have a bearing on achieving the peak bone mass and subsequent development of osteoporosis.</abstract><cop>London</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>7824412</pmid><doi>10.1136/pgmj.70.829.798</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Postgraduate medical journal, 1994-11, Vol.70 (829), p.798-800 |
| issn | 0032-5473 1469-0756 |
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| subjects | Absorptiometry, Photon Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Body Height Bone Density Cross-Sectional Studies Diseases of the osteoarticular system Family Health Female Hand Strength Humans Medical sciences Middle Aged Osteoporosis - genetics Osteoporosis - pathology Osteoporosis. Osteomalacia. Paget disease Skinfold Thickness |
| title | Osteoporosis and genetic influence: a three-generation study |
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