Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast

To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer. Patients with a histologically confirmed diagnosis of previ...

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Veröffentlicht in:	Breast cancer research : BCR 2008-01, Vol.10 (2), p.R30-R30, Article R30
Hauptverfasser:	von Minckwitz, Gunter, Sinn, Hans-Peter, Raab, Günter, Loibl, Sibylle, Blohmer, Jens-Uwe, Eidtmann, Holger, Hilfrich, Jörn, Merkle, Elisabeth, Jackisch, Christian, Costa, Serban D, Caputo, Angelika, Kaufmann, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer Care and treatment Chemotherapy Chemotherapy, Adjuvant Doxorubicin - administration & dosage Female Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Immunohistochemistry Ki-67 Antigen - analysis Logistic Models Lymphatic Metastasis Mastectomy - methods Middle Aged Neoadjuvant Therapy - methods Predictive Value of Tests Prospective Studies Proto-Oncogene Proteins c-bcl-2 - analysis Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tamoxifen - administration & dosage Taxoids - administration & dosage Treatment Outcome Tumor Suppressor Protein p53 - analysis
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