ATF3 Protects against Renal Ischemia-Reperfusion Injury

Oxidative stress-induced cell death plays a major role in the progression of ischemic acute renal failure. Using microarrays, we sought to identify a stress-induced gene that may be a therapeutic candidate. Human proximal tubule (HK2) cells were treated with hydrogen peroxide (H2O2) and RNA was appl...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2008-02, Vol.19 (2), p.217-224
Hauptverfasser:	YOSHIDA, Takumi, SUGIURA, Hidekazu, AKIBA, Takashi, NITTA, Kosaku, MITOBE, Michihiro, TSUCHIYA, Ken, SHIROTA, Satsuki, NISHIMURA, Sayoko, SHIOHIRA, Shunji, ITO, Hiroshi, NOBORI, Kiyoshi, GULLANS, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - physiopathology Adenoviridae - genetics Animals Basic Research Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Line Creatinine - blood Gene Transfer Techniques Humans Hydrogen Peroxide - pharmacology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Oligonucleotide Array Sequence Analysis Oxidants - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology Renovascular diseases Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology Up-Regulation - drug effects Up-Regulation - physiology
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