Flattened cortical maps of cerebral function in the rat: A region-of-interest approach to data sampling, analysis and display
We describe a method for the measurement, analysis and display of cerebral cortical data obtained from coronal brain sections of the adult rat. In this method, regions-of-interest (ROI) are selected in the cortical mantle in a semiautomated fashion using a radial grid overlay, spaced in 15° interval...
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| Veröffentlicht in: | Neuroscience letters 2008-03, Vol.434 (2), p.179-184 |
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| container_end_page | 184 |
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| container_title | Neuroscience letters |
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| creator | Holschneider, D.P. Scremin, O.U. Chialvo, D.R. Kay, B.P. Maarek, J.-M. I. |
| description | We describe a method for the measurement, analysis and display of cerebral cortical data obtained from coronal brain sections of the adult rat. In this method, regions-of-interest (ROI) are selected in the cortical mantle in a semiautomated fashion using a radial grid overlay, spaced in 15° intervals from the midline. ROI measurements of intensity are mapped on a flattened two-dimensional surface. Topographic maps of statistical significance at each ROI allow for the rapid viewing of group differences. Cortical
z-scores are displayed with the boundaries of brain regions defined according to a standard atlas of the rat brain. This method and accompanying software implementation (Matlab, Labview) allow for compact data display in a variety of autoradiographic and histologic studies of the structure and function of the rat brain. |
| doi_str_mv | 10.1016/j.neulet.2008.01.061 |
| format | Article |
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| ispartof | Neuroscience letters, 2008-03, Vol.434 (2), p.179-184 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antipyrine - analogs & derivatives Antipyrine - pharmacokinetics Autoradiography Biological and medical sciences Brain mapping Brain Mapping - instrumentation Brain Mapping - methods Carbon Radioisotopes Cerebral cortex Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiology Fundamental and applied biological sciences. Psychology Radionuclide Imaging Rats Software Topographic maps Vertebrates: nervous system and sense organs |
| title | Flattened cortical maps of cerebral function in the rat: A region-of-interest approach to data sampling, analysis and display |
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