Differential regulation of SOCS genes in normal and transformed erythroid cells

The SOCS family of genes are negative regulators of cytokine signalling with SOCS-1 displaying tumor suppressor activity. SOCS-1, CIS and SOCS-3 have been implicated in the regulation of red blood cell production. In this study, a detailed examination was conducted on the expression patterns of thes...

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Veröffentlicht in:	Oncogene 2003-05, Vol.22 (21), p.3221-3230
Hauptverfasser:	Sarna, Mohinder K, Ingley, Evan, Busfield, Samantha J, Cull, Vanessa S, Lepere, Winald, McCarthy, David J, Wright, Michael J, Palmer, Gene A, Chappell, David, Sayer, Melissa S, Alexander, Warren S, Hilton, Douglas J, Starr, Robyn, Watowich, Stephanie S, Bittorf, Thomas, Klinken, S Peter, Tilbrook, Peta A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cancer Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - physiology Cell Biology Cell Differentiation Cell Line, Transformed Cells, Cultured Cytokines Ectopic expression Erythrocytes Erythroid cells Erythroid Precursor Cells - cytology Erythroid Precursor Cells - drug effects Erythroid Precursor Cells - metabolism Erythropoietin Erythropoietin - pharmacology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene regulation Genes Growth factors Human Genetics Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics Internal Medicine Intracellular signalling Kinases Medical research Medicine Medicine & Public Health Mice Molecular and cellular biology Mutation Oncology original-paper Progenitor cells Promoter Regions, Genetic Protein Biosynthesis Protein-tyrosine kinase Proteins - genetics Receptors, Erythropoietin - genetics Repressor Proteins RNA, Messenger - biosynthesis Signal transduction src-Family Kinases - metabolism Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Transcription Factors Transcriptional Activation Tumor suppressor genes Tumors
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