Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
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| Veröffentlicht in: | Journal of Virology 2008-06, Vol.82 (12), p.6009-6016 |
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| container_title | Journal of Virology |
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| creator | Böttcher, Sindy Maresch, Christina Granzow, Harald Klupp, Barbara G. Teifke, Jens P. Mettenleiter, Thomas C. |
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| doi_str_mv | 10.1128/JVI.00280-08 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.00280-08</identifier><identifier>PMID: 18400848</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Alphaherpesvirus ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Binding Sites - genetics ; Biological and medical sciences ; Cell Line ; Cysteine - genetics ; Endopeptidases - chemistry ; Endopeptidases - genetics ; Fundamental and applied biological sciences. Psychology ; Genetics ; Herpesvirus ; Herpesvirus 1, Suid - genetics ; Herpesvirus 1, Suid - physiology ; Herpesvirus 1, Suid - ultrastructure ; Immunohistochemistry ; In Vitro Techniques ; Kinetics ; Mice ; Mice, Inbred Strains ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Neurons - virology ; Pseudorabies virus ; Serine - metabolism ; Structure and Assembly ; Suid herpesvirus ; Ubiquitin-Specific Proteases ; Viral Structural Proteins - chemistry ; Viral Structural Proteins - genetics ; Viral Structural Proteins - physiology ; Viral Structural Proteins - ultrastructure ; Virion - ultrastructure ; Virology ; Virus Replication - genetics</subject><ispartof>Journal of Virology, 2008-06, Vol.82 (12), p.6009-6016</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-9c0c718293964fc9c9baa47a35e80dd43b7952be0fc1205c39e941ab0b823f3e3</citedby><cites>FETCH-LOGICAL-c568t-9c0c718293964fc9c9baa47a35e80dd43b7952be0fc1205c39e941ab0b823f3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395145/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395145/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20388845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18400848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Böttcher, Sindy</creatorcontrib><creatorcontrib>Maresch, Christina</creatorcontrib><creatorcontrib>Granzow, Harald</creatorcontrib><creatorcontrib>Klupp, Barbara G.</creatorcontrib><creatorcontrib>Teifke, Jens P.</creatorcontrib><creatorcontrib>Mettenleiter, Thomas C.</creatorcontrib><title>Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Article Usage Stats
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</description><subject>Alphaherpesvirus</subject><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution</subject><subject>Animals</subject><subject>Binding Sites - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cysteine - genetics</subject><subject>Endopeptidases - chemistry</subject><subject>Endopeptidases - genetics</subject><subject>Fundamental and applied biological sciences. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>18400848</pmid><doi>10.1128/JVI.00280-08</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-538X |
| ispartof | Journal of Virology, 2008-06, Vol.82 (12), p.6009-6016 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2395145 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alphaherpesvirus Amino Acid Sequence Amino Acid Substitution Animals Binding Sites - genetics Biological and medical sciences Cell Line Cysteine - genetics Endopeptidases - chemistry Endopeptidases - genetics Fundamental and applied biological sciences. Psychology Genetics Herpesvirus Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - physiology Herpesvirus 1, Suid - ultrastructure Immunohistochemistry In Vitro Techniques Kinetics Mice Mice, Inbred Strains Microbiology Miscellaneous Molecular Sequence Data Mutagenesis, Site-Directed Neurons - virology Pseudorabies virus Serine - metabolism Structure and Assembly Suid herpesvirus Ubiquitin-Specific Proteases Viral Structural Proteins - chemistry Viral Structural Proteins - genetics Viral Structural Proteins - physiology Viral Structural Proteins - ultrastructure Virion - ultrastructure Virology Virus Replication - genetics |
| title | Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo |
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