High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration

Abstract Nitric oxide (NO) causes S -glutathiolation of the reactive cysteine-674 in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), thus increasing SERCA activity, and inhibiting Ca2+ influx and migration of vascular smooth muscle cells (VSMC). Because increased VSMC migration contribut...

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Veröffentlicht in:Journal of molecular and cellular cardiology 2008-02, Vol.44 (2), p.361-369
Hauptverfasser: Tong, XiaoYong, Ying, Jia, Pimentel, David R, Trucillo, Mario, Adachi, Takeshi, Cohen, Richard A
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Sprache:eng
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