Overindulgence and metabolic syndrome: is FoxO1 a missing link?

Excessive production of triglyceride-rich VLDL, which can result from dietary overindulgence, underlies metabolic syndrome--a combination of disorders including high blood pressure, obesity, high triglyceride, and insulin resistance--and places individuals at increased risk of developing cardiovascu...

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Veröffentlicht in:	The Journal of clinical investigation 2008-06, Vol.118 (6), p.2012-2015
Hauptverfasser:	Sparks, Janet D, Sparks, Charles E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - metabolism Biomedical research Care and treatment Carrier Proteins - genetics Carrier Proteins - metabolism Diabetes Mellitus, Type 2 - metabolism Fatty Liver - metabolism Fibrosis - metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism Genetic aspects Humans Insulin - metabolism Lipoproteins, VLDL - metabolism Liver - metabolism Low density lipoproteins Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Metabolic syndrome X Mice Models, Biological Physiological aspects Risk factors Triglycerides - metabolism
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