Sirolimus reduces polycystic liver volume in ADPKD patients

The immunosuppressive agent sirolimus exerts an antiproliferative effect by inhibiting mammalian target of rapamycin (mTOR). Because excessive proliferation of the biliary epithelium is a prominent feature of the polycystic liver that accompanies autosomal dominant polycystic kidney disease (ADPKD),...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2008-03, Vol.19 (3), p.631-638
Hauptverfasser:	Qian, Qi, Du, Hui, King, Bernard F, Kumar, Sumedha, Dean, Patrick G, Cosio, Fernando G, Torres, Vicente E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Clinical Research Epithelium - metabolism Female Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Kidney - drug effects Kidney - pathology Kidney Transplantation Liver - drug effects Liver - metabolism Liver - pathology Liver Diseases - diagnosis Liver Diseases - drug therapy Liver Diseases - metabolism Magnetic Resonance Imaging Male Middle Aged Organ Size - drug effects Polycystic Kidney, Autosomal Dominant - surgery Protein Kinases - metabolism Retrospective Studies Ribosomal Protein S6 - metabolism Signal Transduction - drug effects Sirolimus - pharmacology Sirolimus - therapeutic use TOR Serine-Threonine Kinases
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