AMP-activated protein kinase is essential for survival in chronic hypoxia

This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during ch...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-05, Vol.370 (2), p.230-234
Hauptverfasser:	Borger, Darrell R., Gavrilescu, L. Cristina, Bucur, Maria C., Ivan, Mircea, DeCaprio, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMPK Apoptosis Cancer Cell Hypoxia - drug effects Cell Hypoxia - genetics Cell Line, Transformed Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Humans Hypoxia mTOR Protein Kinase Inhibitors - pharmacology Protein Kinases - drug effects Protein Kinases - metabolism Rapamycin Ribonucleotides - pharmacology Sirolimus - pharmacology TOR Serine-Threonine Kinases
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