Short Report : The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans
Lineages of Borrelia burgdorferi , the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C ( ospC ) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; ge...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2008-05, Vol.78 (5), p.806-810 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | DYKHUIZEN, Daniel E BRISSON, Dustin SANDIGURSKY, Sabina WORMSER, Gary P NOWAKOWSKI, John NADELMAN, Robert B SCHWARTZ, Ira |
| description | Lineages of
Borrelia burgdorferi
, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (
ospC
) locus. The lineages marked by
ospC
genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of
B. burgdorferi
present in ticks have a high propensity to disseminate in humans. |
| doi_str_mv | 10.4269/ajtmh.2008.78.806 |
| format | Article |
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Borrelia burgdorferi
, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (
ospC
) locus. The lineages marked by
ospC
genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of
B. burgdorferi
present in ticks have a high propensity to disseminate in humans.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2008.78.806</identifier><identifier>PMID: 18458317</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: Allen Press</publisher><subject>Bacterial diseases ; Biological and medical sciences ; Borrelia infections ; Human bacterial diseases ; Infectious diseases ; Medical sciences ; Tropical bacterial diseases</subject><ispartof>The American journal of tropical medicine and hygiene, 2008-05, Vol.78 (5), p.806-810</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20324508$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>DYKHUIZEN, Daniel E</creatorcontrib><creatorcontrib>BRISSON, Dustin</creatorcontrib><creatorcontrib>SANDIGURSKY, Sabina</creatorcontrib><creatorcontrib>WORMSER, Gary P</creatorcontrib><creatorcontrib>NOWAKOWSKI, John</creatorcontrib><creatorcontrib>NADELMAN, Robert B</creatorcontrib><creatorcontrib>SCHWARTZ, Ira</creatorcontrib><title>Short Report : The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans</title><title>The American journal of tropical medicine and hygiene</title><description>Lineages of
Borrelia burgdorferi
, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (
ospC
) locus. The lineages marked by
ospC
genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of
B. burgdorferi
present in ticks have a high propensity to disseminate in humans.</description><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Borrelia infections</subject><subject>Human bacterial diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Tropical bacterial diseases</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpVj0tLxDAUhYMoOo7-AHfZuOx4k-ZVF4KOTxAUH-uSpqkTmSYlSYXZ-sutKIKrc-8953xwEToisGBUVCf6PferBQVQC6kWCsQWmhEmRUEE49toBgC0qEQp99B-Su8ARFFCdtEeUYyrksgZ-nxehZjxkx2-5RS_rCx-jGGwPrm8waHDl67rbLQ-44sQo107jZsxvrUhTmeH05QcccrRmRzwjfUhbwab8LQs9Zjs1E_J9s7rbFt85ztrsgs-Yefx7dhrnw7QTqfXyR7-6hy9Xl-9LG-L-4ebu-X5fTFQBrnggisAzUXLhWG6AsJK3lApDZPctJJMMzF6Miqg3BLJjK2UahooiVCSlXN09sMdxqa3rZleinpdD9H1Om7qoF393_FuVb-Fj5qWSgInE-D4F6CT0esuam9c-gNQKCnjoMovsTF9ng</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>DYKHUIZEN, Daniel E</creator><creator>BRISSON, Dustin</creator><creator>SANDIGURSKY, Sabina</creator><creator>WORMSER, Gary P</creator><creator>NOWAKOWSKI, John</creator><creator>NADELMAN, Robert B</creator><creator>SCHWARTZ, Ira</creator><general>Allen Press</general><scope>IQODW</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Short Report : The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans</title><author>DYKHUIZEN, Daniel E ; BRISSON, Dustin ; SANDIGURSKY, Sabina ; WORMSER, Gary P ; NOWAKOWSKI, John ; NADELMAN, Robert B ; SCHWARTZ, Ira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-565800a56d56c4a901435b277c475cd71b271caa909025e174ce988bb03168743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Borrelia infections</topic><topic>Human bacterial diseases</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Tropical bacterial diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DYKHUIZEN, Daniel E</creatorcontrib><creatorcontrib>BRISSON, Dustin</creatorcontrib><creatorcontrib>SANDIGURSKY, Sabina</creatorcontrib><creatorcontrib>WORMSER, Gary P</creatorcontrib><creatorcontrib>NOWAKOWSKI, John</creatorcontrib><creatorcontrib>NADELMAN, Robert B</creatorcontrib><creatorcontrib>SCHWARTZ, Ira</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DYKHUIZEN, Daniel E</au><au>BRISSON, Dustin</au><au>SANDIGURSKY, Sabina</au><au>WORMSER, Gary P</au><au>NOWAKOWSKI, John</au><au>NADELMAN, Robert B</au><au>SCHWARTZ, Ira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short Report : The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><date>2008-05-01</date><risdate>2008</risdate><volume>78</volume><issue>5</issue><spage>806</spage><epage>810</epage><pages>806-810</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Lineages of
Borrelia burgdorferi
, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (
ospC
) locus. The lineages marked by
ospC
genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of
B. burgdorferi
present in ticks have a high propensity to disseminate in humans.</abstract><cop>Lawrence, KS</cop><pub>Allen Press</pub><pmid>18458317</pmid><doi>10.4269/ajtmh.2008.78.806</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of tropical medicine and hygiene, 2008-05, Vol.78 (5), p.806-810 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Bacterial diseases Biological and medical sciences Borrelia infections Human bacterial diseases Infectious diseases Medical sciences Tropical bacterial diseases |
| title | Short Report : The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans |
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